Tufts University

New England Medical Center Hospitals. Inc.

Wellesley College

M.i.t.

Other

Massachusetts Institute of Technology

New England Medical Center

Lanny J Rosenwasser

Philip E Auron

Lee Gehrke

Charles A Dinarello

Alexander Rich

Andrew C Webb

Sheldon M Wolff

Disclosed are novel muteins of IL-1 compounds which can be used to regulate excess IL-1 produced in various diseases in humans and animals. The IL-1 muteins can be prepared by site-directed mutagenesis whereby a positively charged residue is replaced with a negatively charged or neutral residue at a designated position in the molecule. The resulting IL-1 muteins have reduced biological activity but retain receptor binding affinity.

Interleukin-1 muteins, their preparation and method of use to inhibit

The subject invention concerns truncated human Il-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.

Human IL-1 cDNA sequences encoding biologically-active human IL-1

The subject invention concerns truncated human IL-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.

Truncated human IL-1 cDNA sequences which encode biologically-active

Truncated protein of interleukin-1

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Weston, MA, United States of America

Lanny J Rosenwasser