Zhejiang University

Shaoxing Tongchuang Biotechnology Co., Ltd.

Hangzhou Chichuang Biotechnology Co., Ltd.

Lanjuan Li

Hui Wang

Jun Li

Xin Chen

Jiang Li

Duan Ma

Yiming Zhang

Weibo Du

Mingfei Yao

Hongcui Cao

Xin Jin

Shengyi Han

Jianrong Huang

Weixin Huang

Bona Wang

Yanmeng Lu

Chihui Yu

Guoliang Lv

Chengbo Yu

Ling Gao

Jiaojiao Xie

Xiaoping Pan

Xufeng Yao

Yuqin Luo

Guoping Sheng

Jialing Yu

Yue Shi

Binghuan Weng

Lin He

Zhiyong Zhu

The invention provides a Probiotic microcapsule and a preparation method thereof, relating to the technical field of Probiotic products. The method includes the following steps: (a) preparing a capsule core containing Probiotics: mixing the capsule core materials including Probiotic powder, microcrystalline cellulose and starch, then adding a hydroxypropyl methylcellulose solution thereinto, while mixing evenly, making the obtained mixture materials into spherical particulate capsule cores by the extrusion spherization method; (b) coating by atomization: coating the microcapsule cores with a coating material solution in a single layer or multiple layers by atomization, getting core-shell microcapsules. The Probiotic microcapsules prepared by the present invention have a large encapsulation, uniform microcapsule particles, controllable particle size, storage-resistance, targetability to intestinal tracts, resistance to gastric acids and high temperature stability.

Probiotic microcapsule and preparation method thereof

A method of treating fulminant hepatic failure in a subject, includes administering a therapeutically effective amount of a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a DLL4 cytokine. A method of treating liver failure, sub-acute liver failure, chronic liver failure or acute-on-chronic liver failure in a subject, includes administering an therapeutically effective amount of a DLL4 cytokine to the subject.

Method of treating fulminant hepatic failure using DLL4 cytokine

The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing. An intrahepatic fibrous vascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct connecting the upper and the lower hepatic bile ducts, and collagen fibrous microchannels for hepatocytes surrounded by the bile capillary network are distributed throughout the nanofiber scaffold. Bile capillaries in the bile capillary network are provided with two or more inlet ports for biliary epithelial cells. The collagen fibrous microchannels for hepatocytes are provided with two or more inlet ports for hepatocytes. The intrahepatic vascular network is provided with a liquid inlet port and a liquid outlet port. These ports extend through the housing.

Hepatic lobule-like bioreactor

Growing community of inventors

Zhejiang, China

Lanjuan Li