USA As Represented by Secretary of the Navy

Lanfong H Lee

Patricia Guerry

Trevor J Trust

Edward Burg

This invention comprises a recombinant protein comprising the maltose binding protein (MBP) offused to amino acids 5&#x2013;337 of the FlaA flagellin ofVC167 which has provided evidence of immunogenicity and protective efficacy against challenge by a heterologous strain of81&#x2013;176 in mammals. The invention further comprises a recombinant DNA construct encoding the immunodominant region (region I through III) of flagellin fromspp. for use as a component of a vaccine againstdiarrhea. The invention therefore represents an effective treatment againstbut avoids inducing the autoimmune Guillain Barre Syndrome (GBS), a post-infection polyneuropathy caused bymolecular mimicry of human gangliosides which has hampered the development of vaccines heretofore.

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Silver Spring, MD, United States of America

Lanfong H Lee