Crystal Fibre A/s

Acuitas Medical Limited

Osteotronix Medical Pte Limited

Lance W Farr

Timothy W James

David R Chase

Brian Joseph Mangan

Jonathan N Stearn

Hendrik Sabert

James Rafferty

John Roberts

A method of assessing a spatial frequency distribution within a sample comprising subjecting the sample to magnetic resonance excitation, receiving an echo signal from the sample while the sample is subjected to a magnetic field gradient, applying an invertible linear transform to the echo signal, identifying a region of interest in the transformed echo signal and deriving a corresponding window function, applying the window function (in the signal or transform domain) to the echo signal to remove echo signal coming from regions of the sample outside of the region of interest, and analyzing the one dimensional spatial frequency content in the windowed echo signal in order to access a one dimensional spatial frequency distribution within the region of interest within the sample without creating an image.

Localised one-dimensional magnetic resonance spatial-frequency spectroscopy

In a structural analysis using NMR techniques, a method for gathering k-value data from frequency encoded spin echoes generated from internal volumes selectively excited by intersecting 90&#xb0; and 180&#xb0; slice selective and refocusing RF pulses and subjected to a read gradient for the purpose of quantifying the spatial frequency content of the selected internal volume without contamination by a FID signal, comprising: acquiring spin echo data such that the FID signal generated by imperfections in the 180&#xb0; slice selective refocusing RF pulse is attenuated by the read gradient such that any remaining FID signal is spatially encoded with higher k-values than the frequency encoded k-values being recorded for subsequent structural analysis while simultaneously providing for t2 t2* and t1 contrast. Other aspects of the invention are disclosed.

Optimised pulse sequences for evaluating spatial frequency content of a selectively excited internal volume

A method for representing the structural information in a biological or physical sample is disclosed. In this method, a time-frequency representation of the spatial distribution within a sample is transformed into a color representation of the data. Furthermore, due to the directional sensitivity of the method for gathering the data, information about the structural anisotropy of the sample can also be encoded from the data. The application of this method to one or more regions within the sample enables a map to be generated which clearly illustrates quantitative measures of the structures present.

Representation of spatial-frequency data as a map

An optical fiber having a cladding region surrounding a core region having an elongate core hole, the inner or outer surface of the core hole having a surface roughness with a spatial period equal to or less than 5 &#x3bc;m by a spectral power below 0.0017 nm&#x3bc;m. A method of making an optical fiber including a cladding region having an arrangement of elongate cladding holes in a matrix material, surrounding an elongate core region having an elongate core hole, the method including the step of increasing the surface tension of the matrix material prior to or during the step of heating and drawing the fiber.

Hollow-core optical fiber and method of making same

A photonic optical fiber and method of making the optical fiber. The method includes assembling a plurality of elongate elements to define an elongate void; forming within the void a material contacting at least some of the elements while maintaining the elongate void; and drawing a preform, including the assembly of elongate elements, into an optical fiber.

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Hereford, United Kingdom

Lance W Farr