Roche Diagnostics Operations, Inc.

Roche Operations Ltd.

Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Corange International Limited

Lance Scott Kuhn

David W Burke

Terry Allen Beaty

Vladimir Svetnik

James F Maxwell

Mary L Ochs

Rebecca W Muddiman

Robert J McEnroe

Mary E Brown

Hans-Joachim Guder

P Douglas Walling

Chi-Neng Arthur Han

Martin T Gerber

Klaus H Pollmann

Joseph E Bateson

John G Hurrell

Kent M Kost

Gilbert C Morris

M Luann Ochs

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

Method for determining whether a disposable, dry regent, electrochemical test strip is unsuitable for use

System and method for analyte measurement

System and method for determining an abused sensor during analyte measurement

Control and calibration solutions are described that provide control and calibration data that is recognized by a test meter allowing the meter to segregate the control and calibration data from regular test data. Recognition and segregation of the control and calibration data can occur automatically with no additional input from the meter's user. Methods for use of the solutions are also provided.

Control and calibration solutions and methods for their use

System and method for analyte measurement employing maximum dosing time delay

System and method for determining a temperature during analyte measurement

System and method for analyte measurement using AC excitation

System and method for analyte measurement using AC phase angle measurements

An apparatus and method for determining the concentration of a medically significant component of a biological fluid comprise providing a cell supporting a chemistry which reacts with the medically significant component. Placement of first and second terminals of the cell in contact with first and second terminals, respectively, of an instrument permits the instrument to assess the reaction. The instrument determines a first response of the cell to a first signal, and determines based upon the first response whether to proceed with the determination of the concentration of the medically significant component of the biological fluid. If the determination is to proceed, the instrument determines the type of sample that has been applied. If the sample is a sample of a particular type, the instrument determines a first correction value based upon the cell's response to the third signal and combines the correction value with the result of the reaction assessment to produce an indication of the concentration of the medically significant component in the sample.

Meter and method of using the meter for determining the concentration of a component of a fluid

A diagnostic kit, method, and apparatus for electrochemically determining the presence or concentration of an analyte in a sample. A mixture is formed which includes the sample, an enzyme acceptor polypeptide, an enzyme donor polypeptide, and a labeled substrate. The enzyme donor polypeptide is capable of combining with the enzyme acceptor polypeptide to form an active enzyme complex. The formation of such the active enzyme complex is responsive to the presence or concentration of the analyte in the fluid sample. The active enzyme hydrolyzes the labeled substrate, resulting in the generation of an electroactive label, which can then be oxidized at the surface of an electrode. A current resulting from the oxidation of the electroactive compound can be measured and correlated to the concentration of the analyte in the sample.

Electrochemical enzyme assay

A new electrochemical biosensor and method of its use. The electrochemical biosensor has a pair of electrodes consisting of a working electrode and a counter electrode made of the same electrically conducting materials. The counter electrode may be the same size or smaller than the working electrode. The biosensor includes a sample receiving portion wherein a portion of the electrode surfaces is covered by a reagent that includes a redox mediator and an enzyme. A fluid that contains an analyte is added to the sample receiving portion. A reaction involving the analyte, enzyme and redox mediator occurs. After this reaction is complete, an electrical potential difference is applied between the electrodes. Diffusion limited current is measured and correlated to the concentration of analyte in the fluid.

Assay method with enzyme electrode system

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Fishers, IN, United States of America

Lance Scott Kuhn