Boehringer Ingelheim Animal Health USA Inc.

Sanofi

Lance Hammerland

Brenda Bondesen

Werner Dittrich

Eric Tagat

Michel Partiseti

Rachid Boukaiba

Thierry Vermat

Qing Zhou-Liu

Jean-Marie Chambard

Cathy Cojean

The present invention relates to a veterinary composition comprising an effective amount of at least one cyclic depsipeptide and at least one macrocyclic lactone; and a pharmaceutically acceptable carrier, for the treatment or prophylaxis of parasitic infection in a mammal wherein the parasite shows resistance to treatment or prophylaxis with the macrocyclic lactone alone.

Anthelmintic combinations and methods of use thereof

The following discloses mammalian cells lines that stably express functional nematode acetylcholine receptor subunits. The resulting expression of functional ion channels has been made possible by the stable co-expression of the chaperone protein, RIC3. These cell lines are extremely useful for the high throughput screening (HTS) of compounds, to identify new candidate parasiticidal, including nematocidal, active ingredients.

Mammalian cell lines expressing functional nematode acetylcholine receptors and use thereof for high-throughput screening assays

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Auburn Hills, MI, United States of America

Lance Hammerland