Third Wave Technologies, Inc.

Lance Fors

Victor I Lyamichev

Fang Dong

Bruce P Neri

Mary Ann D Brow

James Robert Prudent

James E Dahlberg

Todd A Anderson

Mary Ann Brow

Laura M Heisler

The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).

Methods for analyzing nucleic acid

Methods for genotyping hepatitis C virus

The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).

Target-dependent reactions using structure-bridging oligonucleotides

Polymorphism analysis by nucleic and acid structure probing

Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides

The present invention relates to methods and compns. for treating nucleic acids, and in particular, methods and compns. for the detection and characterization of nucleic acid sequences and sequence changes. The invention provides methods for examg. the conformations assumed by single strands of nucleic acid, forming the basis of novel methods of detection of specific nucleic acid sequences. The present invention contemplates use of novel detection methods for, among other uses, clinical diagnostic purposes, including but not limited to the detection and identification of pathogenic organisms. Examples are presented for the analysis of and hepatitis C virus genes.

Polymorphism analysis by nucleic acid structure probing

The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to screen for known and unknown mutations, including single base changes, in the human p53 gene. Methods are provided which allow for the identification of genetic mutations in the human p53 gene in a sample.

Rapid detection of mutations in the p53 gene

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Madison, WI, United States of America

Lance Fors