Hangzhou Minsheng Pharmaceutical Co. Ltd

Purdue Pharmaceuticals Products L.p.

Hangzhou Minsheng Institutes for Pharma Research

Euro-celtique S.a.

Hangzhou Minsheng Pharmaceuticals Co., Ltd.

Lan Yang

Dianwu Guo

Feiyu Feng

Qiufu Ge

Yi Heng Chen

Yu Cheng Chen

Ximing Shen

Shulong Wang

Binnan Huang

Zhenhua Liu

Zhonghua Peng

Jian Cai

Yu Chen

Yi Chen

A class of quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof with novel structures is provided; meanwhile, a pharmaceutical composition comprising a pharmaceutically effective amount of said quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof, and pharmaceutically acceptable excipients or additives is also provided. By modifying and transforming the quinazoline and screening of the transformed compounds on the activity of tyrosine kinase inhibition, most of the compounds have been found to possess inhibitory activity against one or several of EGFR, VEGFR-2, c-erbB-2, c-erbB-4, c-met, tie-2, PDGFR, c-src, lck, Zap70 and fyn kinases. The present invention has the advantages of reasonable design, broad source of and easy access to the raw materials, simple and easy operation of the preparation methods, mild reaction conditions, high yield of the products and being beneficial for industrial-scale production.

Quinazoline derivative, composition having the derivative, and use of the derivative in preparing medicament

The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X, X, Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.

Pharmaceutical compositions

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Hangzhou, China

Lan Yang