Symphar S.a.

Ilex Products, Inc.

Other

Smithkline Beecham Corporation

Ilex Oncology Research S.a.

Lan Mong Nguyen

Eric Joseph Niesor

Craig Leigh Bentzen

Hieu Trung Phan

Robert John Ife

Vinh Van Diep

Raymond Azoulay

Yves Guyon-Gellin

Simon Floret

Alexandre Bulla

Pierre Maechler

Jean-Luc Thuillard

Harald Eschenhof

Jean Flach

The present invention relates to novel &#x3b2;-substituted-&#x3b2;-aminoethylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

&#x3b2;-substituted &#x3b2;-aminoethyl phosphonate derivatives

The present invention relates to novel &agr;-substituted-&bgr;-aminoethylphosphonate and &agr;-substituted-&bgr;-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

&agr;-Substituted &bgr;-aminoethyl phosphonate derivatives

Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity.

Compounds and pharmaceutical compositions containing them

Aminophosphonates alpha substituted by phenol groups, of formula (I) have lipoprotein(a) lowering activity.

Pharmaceutical aminophosphonic acid derivatives

Use of phenol substituted diphosphonates as antineoplastic agents

The present invention relates to novel aminophosphonate derivatives substituted in .alpha. position by phenol groups, of formula (I): ##STR1## in which: X.sup.1, X.sup.2, X.sup.3, R.sup.1, R.sup.2, A, B, Z and n are defined in claim 1, as well as their preparations and the pharmaceutical compositions comprising them.

Substituted aminophosphonate derivatives, process for their preparation

The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions containing them.

Method for lowering plasma lipid levels or blood pressure

Phenol substituted gem-diphosphonate derivatives, process for their

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Nyon, Switzerland

Lan Mong Nguyen