Systimmune, Inc.

Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Sichuan Baili Pharmaceutical Co. Ltd.

Baili-Bio Pharmaceutical Co., Ltd.

Lan Chen

Yi Zhu

Shi Zhuo

Brian Robert Kovacevich

Zeren Gao

Blair R Renshaw

Phil Tan

Jeffrey B Adamo

Jie Li

Yongguo Yu

Yixi Wang

Nga Sze Amanda Mak

Weili Wan

Nge Sze Amanda Mak

Nga Sze Mak

A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.

Bispecific tetravalent antibodies and methods of making and using thereof

By inserting cysteine (C) into a heavy chain and/or a light chain of a target antibody at specific insertion site, and performing a site-specific conjugation through a free thiol group (&#x2014;SH) from the site-specific inserted cysteine and a linker conjugated with a highly potent small molecule cytotoxin, a cysteine modified antibody-drug conjugate with good homogeneity is provided. The specific insertion sites of cysteine are position 205 and/or position 206 (Kabat numbering scheme) of the light chain of the antibody, and/or position 439 (Kabat numbering scheme) of the heavy chain.

Cysteine modified antibody-drug conjugate and preparation method thereof

Growing community of inventors

Chengdu, China

Lan Chen