Hyalex Orthopaedics, Inc.

Biomimedica, Inc.

Leland Stanford Junior University

Eli Lilly and Company

The United States Government As Represented by the Department of Veterans Affairs

Emergence Venture Partners, LLC

Hyalex Orthopedics, Inc.

Lampros Kourtis

David Myung

Michael J Jaasma

Vernon Raymond Hartdegen

Daniel Chang

Jun Li

Iraklis Kourtis

Bing Yu

Timothy Sun

Curtis W Frank

Robert S Ward

Keith R McCrea

Dennis R Carter

Stuart Barry Goodman

Laura Hartmann

Michael Chad Hollis

Jeffrey L Ellis

Anthony David Duong

Corrie Bennison

Sean Matthew Pszenny

Jeffrey G Roberts

John Paul Tallarico

Oliver Brian Regele

Rhea Sirkar

Michael W Harrison

Chloe Marie Funkhouser

Gary Li

Yelena Nikolayevna Davis

Clark Edward Fortney

Steven Eldridge Huckaby

Uri Eliezer Baruch

Xiangnan Dang

Matthew Keith Fordham

Alison Claire Hart

Rachel Rebecca Spurbeck

Eric Christopher Meyers

Leigh Robert Shelford

Thomas Jack Stearn

Stephanie Michelle Kute

Jian Yang

Philip James Owen

Jessica Alice Platt

Christopher Shane Lanham

Joshua Richard Branch

Klaus Theodor Gottlieb

Brian Ellis Winger

Nathan Joseph Platfoot

Curt Frank

Nicholas Vincent Annetta

Matthew James Ash

Cory William Baker

Maria Fernandez-Martos Balson

Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

Polymeric adhesive for anchoring compliant materials to another surface

A chemical reaction system is disclosed for use in a device for delivering a therapeutic fluid comprising a liquid base and a polymeric acid. A reaction rate of the chemical reaction system is capable of being adjusted by adjusting at least one of surface area-to-volume ratio, acid concentration, and cross-linking of the polymeric acid.

System for controlling gas generation within a drug delivery device

An injection device assembly including a housing, a syringe, a drive mechanism and a status sensing system and a module are described. The drive mechanism advances the syringe from a storage position to an injection position, and a plunger advances the syringe piston from an initial position to a final position. The status sensing system includes a light emitter that emits electromagnetic radiation into the housing transverse to the longitudinal axis, a light detector and a controller. The system determines a current status condition from at least three of the following five status conditions: 1) an injection ready state; 2) a needle insertion state; 3) a drug delivered state; 4) a needle guard present state; and 5) a needle retraction state.

Status sensing system for injection device

The present disclosure pertains to ionic polymer compositions, including semi.- and fully interpenetrating polymer networks, methods of making, such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging, for such articles.

Ionic polymer compositions

The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

IPN compositions and methods of making the same are provided. The IPN compositions can include a water swellable, water permeable IPN or semi-IPN member with a first polymer network including a hydrophobic thermoset or thermoplastic polymer, a second polymer network including a non-ionic polymer, and a third polymer network including an ionic polymer containing sulfonic acid functional groups that are otherwise difficult to form composites with hydrophobic polymers. The IPN compositions can be used in orthopedic implants or in mechanical applications as a bearing material.

Interpenetrating polymer networks

Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or composition gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.

Orthopedic implants having gradient polymer alloys

Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or compositional gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.

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Cambridge, MA, United States of America

Lampros Kourtis