Wyeth

American Cyanamid Company

Zealand Pharma A/s

Lalitha Krishnan

Subodh S Deshmukh

Jianxin Ren

Ting-Zhong Wang

Panolil C Raveendranath

Mahmoud Mirmehrabi

John Leo Considine

Karen Sutherland

Maotang X Zhou

Asaf Ragim Alimardanov

Charles Chao Wu

Jason Brazzillo

Gary Paul Stack

Amedeo A Failli

Jeremy Ian Levin

Annmarie Louise Sabb

Reinhardt Bernhard Baudy

Bogdan Kazimierz Wilk

Mannching Sherry Ku

Joseph Zeldis

Anthony Francis Hadfield

Richard A Leese

Anita Wai-Yin Chan

Deborah Ann Evrard

Robert Lewis Vogel

Jean Schmid

Yanfang Li

Martin Tobkes

Charles Guinosso

Wei Tong

Antonia Nikitenko

Jean Yi-ching Sze

Raghavan Krishnan

Huan-Qiu Li

Abdolsamad Tadayon

Simon Diaz

Peter John Larkin

Jennifer P Varriano

Zhixin Wen

Mellard Jennings

Charles John Stanton, Iii

Jean Marie Akin

W James Huang

James W Huang

Anthony Hadfield

Karen Wiggins Sutherland

Charles C Wu

Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

Synthesis of pyrrolidine compounds

Crystalline solid forms of tigecycline, Form I, Form II, Form III, Form IV, and Form V, compositions comprising these crystalline solid forms, and processes for preparing these crystalline solid forms are described herein.

Crystalline solid forms of tigecycline and methods of preparing same

This invention relates to crystalline polymorphs of (3S)-N-hydroxy4-({4-[(4-hydroxy-2-butynyl)oxy]phenyl}sulfonyl)-2,2-dimethyl-3-thiomorpholine carboxamide, and preparation and uses thereof.

Crystalline polymorphs of (3S)-N-hydroxy-4-({4-[-(4-hydroxy-2-butynyl)oxy]phenyl}sulfonyl)-2,2-dimethyl-3-thiomorpholine carboxamide

The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HTreceptors and modulating serotonin levels.

Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives

Processes for using a compound of formula III: to make compounds of formulae I and II: and processes for making the compound of formula III, where Rand J are as defined herein.

Method for preparing hydroxamic acids

Process for the preparation of 2-&lsqb;alkyl(aryl)&rsqb;sulfonylbenzene-sulfonyl chlorides and their intermediates

The invention provides a method for selectively extracting a compound of formula I: ##STR1## wherein: R is hydrogen or --NR.sub.3 R.sub.4 ; and when R=--NR.sub.3 R.sub.4, R.sub.3 and R.sub.4 may be the same or different and are selected from hydrogen and straight or branched (C.sub.1 -C.sub.4)alkyl; R.sub.1 and R.sub.2 may be the same or different and are selected from straight or branched (C.sub.1 -C.sub.6)alkyl; from an aqueous mixture containing a compound of Formula I, its C-4 epimer and its oxidative degradation by-products by adding methylene at a concentration of 2-4 ml of methylene chloride per gram of compound of Formula I and at a pH between pH 6.5-8.0; and obtaining an extract containing methylene chloride, a compound of Formula I, and its C-4 epimer, said epimer being present in an amount of less than 3% of the amount of the compound of Formula I.

Method for selective extracting a 7-(hydrogen or substituted

The invention is an improvement in isolating vancomycin from an aqueous solution of pH 5 to 9 which comprises separating the vancomycin from the solution by adding an alkali or alkaline earth metal inorganic salt to the solution.

Vancomycin precipitation process

An improved process for producing the antibiotic compound clindamycin phosphate through the use of novel intermediate, 7(S)-chloro-7-deoxylincomycin-2-bis(2,2,2-trichloroethyl)phosphochloridate and similar compounds.

Clindamycin phosphate synthesis

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Suffern, NY, United States of America

Lalitha Krishnan