Syntex (u.s.a.) Inc.

Other

Vallinex, Inc.

Lakshmi Sangameswaran

Stephen Gregory Delgado

Linda Marie Fish

Ronald Herman

Douglas Kenneth Rabert

Paul Shartzer Dietrich

Susan Kramer

Ronald Charles Herman

This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical composition. In certain embodiments of the invention, the capsaicinoid is capsaicin.

Instillation administration of capsaicinoids for the treatment of pain

The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.

Method of modulating tetrotodoxin-resistant sodium channel

Human peripheral nerve, tetrodotoxin-resistant sodium channel &agr;-subunit polypeptide

DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.

Cloned tetrodotoxin-sensitive sodium channel &agr;-subunit and a splice variant thereof

Cloned peripheral nerve, tetrodotoxin-resistant sodium channel &agr;-subunit

Cloned tetrodotoxin-sensitive sodium channel .alpha.-subunit and a

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San Jose, CA, United States of America

Lakshmi Sangameswaran