Biocon Limited

Lakshmi Prabha Varadarajalu

Ramakrishnan Melarkode

Kedarnath Nanjund Sastry

Shrikumar Suryanarayan

Akundi Venkata Sriram

The present invention relates to a method of producing a biologically active polypeptide having insulinotropic activity, the method comprising steps of: (a) transforming a genetically modified host cell that has protease gene knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformed host cell to produce the biologically active polypeptide; and a method of producing a biologically active polypeptide having an N-terminal recognition site His-Gly with insulinotropic activity, the method comprising steps of: (a) transforming a genetically modifiedthat has protease gene STE13 knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformedto produce the biologically active polypeptide.

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Bengaluru, India

Lakshmi Prabha Varadarajalu