Council of Scientific and Industrial Research

Lakshmi Manickavasagam

Girish Kumar Jain

Naibedya Chattopadhyay

Amit Kumar

Rakesh Maurya

Anil Kumar Dwivedi

Man Mohan Singh

Ritu Trivedi

Atul Goel

Divya Singh

Sumit Chaurasia

Kamal Ram Arya

Abnish Kumar Gautam

Rashmi Pandey

Preeti Rawat

Kunal Sharan

Jawed Akhtar Siddiqui

Gaurav Swarnkar

Geetanjali Mishra

The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R, R, R, R, R, R, R, Rare independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein RRor RRor RRmay be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C&#x2014;OH, C-Me, C&#x2014;OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders. 

Substituted benzfurochromenes and related compounds for the prevention and treatment of bone related disorders

The present invention provides a flavonol compound and a bioactive extract/fraction fromuseful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R&#x2550;R&#x2550;OH K012: R&#x2550;R&#x2550;OH, 2,3 double bond K068: R&#x2550;R&#x2550;H KIOOi R&#x2550;OH, R&#x2550;H mula 2 Wherein the marker compounds K012, K058, K068, K1OO ranges 6.7-12%, 1.7-4.5%, 0.6-1.2%, 1.7-4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route. 

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Lakshmi Manickavasagam