Sunovion Pharmaceuticals Inc.

Lakshmi D Saraswat

Michele L R Heffernan

Larry Wendell Hardy

Frank Wu

Kerry Leigh Spear

Michele L Heffernan

Frank Xinhe Wu

Compounds that modulate GluR5 activity and methods of using the same are disclosed.

Metabotrophic glutamate receptor 5 modulators and methods use thereof

Metabotrophic glutamate receptor 5 modulators and methods of use thereof

Provided herein are compounds of formula (I): and pharmaceutical compositions thereof, useful for the treatment of disorders mediated by metabotropic glutamate receptor 5.

Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof

Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

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Sudbury, MA, United States of America

Lakshmi D Saraswat