Icahn School of Medicine at Mount Sinai

New York University

Sociedade Beneficente De Senhoras Hospital Sirio Libanes

Lakshmi Arehole Devi

Raphael Rozenfeld

Andrea Sterman Heimann

Bryen Alexander Jordan

Camila Squarzoni Dale

Compounds and compositions useful for the treatment of liver diseases and methods of treating liver diseases are disclosed. The compounds of the invention specifically interact with heteromers of cannabinoid receptors as compared to monomers or homodimers. The invention also relates to methods of screening for compounds useful for the treatment of liver diseases and to methods of screening for diacylglycerol lipase inhibitors.

Methods of screening compounds useful for treatment of a liver disease

Antibodies which bind type I cannabinoid receptor/angiotensin II receptor heteromers and methods of use

The present invention refers to a pharmaceutical composition that includes an active ingredient, such as a peptide, which acts as an antagonist and/or inverse agonist of a G protein-coupled receptor and pharmaceutically acceptable vehicle. The pharmaceutical composition may be used for the treatment of obesity and the prevention of and the treatment of diabetes.

Pharmaceutical composition for treating medical conditions and a method for treating alimentary disorders and related diseases

Antibodies which bind type I cannabinoid receptor/angiotensis II receptor heteromers

Opioid receptors form functional heterodimers with each other and with other G-protein coupled receptors, such as dopamine receptors, adrenergic receptors, or chemokine receptors. These receptors can be exploited for high throughput screening of compounds to identify heterodimer opioid receptor modulators (agonists and antagonists). The invention also relates to identification of novel heterodimer receptor ligands and synergistic compositions, which can provide strategies for analgesia, narcotic addiction, hypertension, HIV infection, and immune system function.

Heterodimeric opioid G-protein coupled receptors

Growing community of inventors

New Rochelle, NY, United States of America

Lakshmi Arehole Devi