H. Lundbeck A/s

Synaptic Pharmaceutical Corporation

Lexicon Pharmaceuticals, Inc.

Rafael Pharmaceuticals, Inc.

Thomas P. Blackburn

Lakmal W. Boteju

Ian Jamie Talisman

Mathivanan Packiarajan

Heidi Chen

Michael Konkel

Stewart Noble

John M. Wetzel

Kitae Lim

Hermo Jimenez

Bharat Lagu

Lakmal W Boteju

David John Augeri

Kenneth Gordon Carson

Robert G Shorr

Stewart Alwyn Noble

John M Wetzel

Thomas Kwok

Theodore C Jessop

Paul M Bingham

Jeffrey Thomas Bagdanoff

Michael J Konkel

James Marecek

Thomas P Blackburn

Robert Rodriguez

David S Kimball

Jeffrey Bagdanoff

David J Augeri

Kenneth G Carson

This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety. This invention also provides a method of treating depression and/or anxiety in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GAL3 receptor antagonist.

Use of GAL3 antagonist for treatment of depression and/or anxiety and compounds useful in such methods

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Cedar, NJ, United States of America

Lakmal W Boteju