Richter Gedeon Vegyeszeti Gyar Rt

Gyogyszerkutato Intezet Kft.

Egyt Gyogyszervegyeszeti Gyar

Basfaktiengesellschaft

Biogal Gyogyszergyar

Gyogyszerkutato Inteezet/pharmaceutical Research Institute

Lajos Toldy

Ferenc Andrasi

Zoltan Zubovics

Janos Borvendeg

Inge Schafer

Laszlo Sebestyen

Zsuzsanna Fittler

Katalin Goldschmidt

Erzsebet Mago Nee Karacsony

Sandor Solyom

Katalin Szilagyi Nee Farago

Istvan Sziraki

Valeria Vitkoczi

Klara Sutka

Eszter Hodula

Antal Simay

Laszlo Tardos

Jozsef Reiter

Tibor Lang

Peter Matyus

Ilona Hermann Nee Szente

Eleonora Szondy

Jozsef Borsy

Lajos Farkas

Eva Gal

Tivadar Rettegi

Erzsebet Zara

Agnes Papp

Mariann Kurti

Marta Rusz

Ildiko Mathe

Laszlo Szporny

Kalman Harsanyi

Elemer Ezer

Gyorgy Fekete

Bela Hegedus

Istvan Elekes

Judit Matuz

Peter Aranyi

Katalin Saghy

Pal Berzsenyi

Tibor Balogh

Endre Kasztreiner

Gyorgy Domany

Gyorgy Cseh

Sandor Elek

Istvan Horvath

Eva Againe Csongor

Gyorgy Rabloczky

Gabor Zolyomi

Jozsef Borsi

Laszlo Pongo

Endre Csanyi

Geza Szilagyi

Andras Varro

Tibor Horvath

Margit Bidlo Nee Igloy

Ildiko Kiraly

Andras Ronai

Ferenc Morasz

Eva Kiss

Andras Rado

Ferene Andrasi

Andras Ronay

Arpad Lazar

Tibor Hasko

Erzsebet F Birkas

Erno Koltai

Katalin Szilagyi

Katalin Gorgenyi

Jozsef Gyimesi

Tamas Somorai

Ilona Berzetei

Aliz Druga

Tibor Somogyi

Oszkar Fuchs

Gizella Abraham

Ilona S Nee Hermann

An N-benzoylamino acid compound of the formula (I), ##STR1## wherein R.sup.3 is an NR.sup.4 R.sup.5 group where R.sup.4 and R.sup.5 which are the same or different are selected from the group consisting of hydrogen, a hydroxyl group, a C.sub.1-12 alkyl group, a C.sub.1-4 alkyl group substituted by a hydroxyl group and a C.sub.1-4 alkyl group substituted by an amino group;

N-benzoylamino acid derivatives, pharmaceutical compositions containing

The invention relates to novel N-benzoylamino acid derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, stand for a hydroxyl group optionally bearing an acetyl group; or a C.sub.1-6 alkoxy group optionally substituted by a phenyl group;

N-benzoyl amino acid derivatives pharmaceutical compositions containing

This invention relates to novel compounds of the general formula (I) and the pharmaceutically acceptable acid addition salts thereof. In the general formula (I) ##STR1## wherein Lip, A.sup.1, A.sup.2, Het and n are defined as in the specification. The compounds of the general formula (I) inhibit the lipid peroxidation and therefore, they are useful for the treatment or prevention of diseases and conditions wherein the inhibition of lipid peroxidation is desirable.

Piperazine and homopiperazine derivatives, pharmaceutical compositions

The present invention relates to novel compounds of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently from each other, for hydrogen, C.sub.1-4 alkyl, phenyl, phenyl-C.sub.1-4 alkyl, piridyl or piridyl-C.sub.1-4 alkyl group;

Novel thiouracyl derivatives, pharmaceutical compositions containing

The invention is directed to 1-(2,6-Dimethyl-Phenyl-amino)-2-Dimethyl-amino-Propane and the pharmaceutical composition thereof useful for the treatment of cardiac rhythm disorders.

New alkylene diamine derivatives

A novel 1,1,2-triphenylpropene derivative, namely: ##STR1## acts on the endocrine system of rats. It exerts oestrogenic or antioestrogenic effects of varying strength in rats, and furthermore inhibits the growth of the mammary tumor induced by 7,12-dimethyl-benz(a)anthracene in rats.

1,1,2-triphenylpropane and -propene derivatives

The invention relates to new pregnene derivatives of the general formula (I), ##STR1## wherein R.sup.1 stands for a C.sub.1-4 alkyl group;

Novel 20 benzcylamino pregnene derivatives and process for preparing same

The invention relates to novel pyrazole derivatives with an ergoline skeleton of the general formula I, ##STR1## wherein x . . . y stands for a ##STR2## R is a hydrogen atom or methyl group, R.sub.1 stands for a hydrogen atom, C.sub.1-4 alkyl, carbethoxy or pyridyl-group,

Pyrazole derivatives with an ergoline skeleton, their acid addition

The invention relates to the new monohydrate of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne (cimetidine), a histamine-H.sub.2 receptor antagonist which is called N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne H (cimetidine H) as well as to a process for the preparation of same, which comprises pouring a hot, homogeneous aqueous solution of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne, optionally containing also methylamine, onto ice and separating the N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne monohydrate.

Cimetidine monohydrate

The invention relates to acylated 1,2,4-triazole derivatives of general formula I ##STR1## wherein R.sup.1 represents an unsubstituted phenyl group or a phenyl group substituted by one or more halogen atoms, lower alkyl, alkoxy, acyloxy, hydroxy, amino, azido, nitro, trifluoromethyl, lower alkylthio, alkylsulfinyl, or alkylsulfonyl group, and

Antiviral acylated 1,2,4-triazole derivatives

A compound of the general formula (I), ##STR1## is described wherein R.sup.1 and R.sup.5 each represent a phenyl group optionally substituted with 1 to 3 lower alkoxy, halo, lower alkyl, monohalo-(lower)-alkyl, dihalo-(lower)-alkyl and/or trihalo-(lower)-alkyl groups, R.sup.2 stands for hydrogen or a lower alkyl group optionally substituted with a hydroxy group or 1 to 3 halogen atoms, R.sup.3 and R.sup.4 each represent a hydrogen atom or a lower alkyl group, and R.sup.6 stands for a carbamoyl, thiocarbamoyl or amidino group having optionally one or two lower alkyl and/or lower alkoxycarbonyl substitutes, or a group of the general formula R.sup.7 -CO-wherein R.sup.7 stands for a lower analkoxy group, an aryloxy group, or an aralkoxy group, and n is equal to 0, provided that when R.sup.1 and R.sup.5 each represent a phenyl group, R.sup.2 and R.sup.3 may not stand for hydrogen or a pharmaceutically acceptable acid addition salt, a pure isomer or an isomeric mixture thereof. The compounds posses antiphlogistic and diuretic activity.

1,3-Diaryl-2-imino-imidazolidines and compounds

Compounds of the formula (I) having aldosterone-antagonizing activity are disclosed ##STR1## wherein R.sub.3 and R.sub.4 are each C.sub.1 to C.sub.3 alkyl; and

Substituted steroid-spiro-oxazolidinone derivatives and a process for

The invention relates to new ergol-8-ene and ergoline derivatives of the general formula /I/ ##STR1## wherein x y stands for --CH.dbd.C.dbd. or --CH.sub.2 --CH.dbd. group,

Novel ergol-8-ene and ergolin compounds and process for preparing same

The invention relates to new compounds of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.5 each represent a phenyl group, optionally substituted,

1,3-Diaryl-2-imino-imidazolidines and compositions thereof

The invention relates to new 8.beta.-hydrazinomethyl-ergoline derivatives of the general formula (I), ##STR1## wherein x y stands for a ##STR2## or ##STR3## group, R stands for hydrogen or methyl group, and

Biologically active new 8.beta.-hydrazinomethyl-ergoline derivatives and

Growing community of inventors

Budapest, Hungary

Lajos Toldy