Richter Gedeon Vegyeszeti Gyar Rt

Patentbureau Danubia

Mta Kozponti Kemiai Kutato Intezete

Lajos Kisfaludy

Laszlo Szporny

Eva Palosi

Egon Karpati

Istvan Schon

Szabolcs Szeberenyi

Olga Nyeki Nee Kuprina

Adam Sarkadi

Tamas Szirtes

Bela Szende

Laszlo Rogdi

Julia Rohricht

Gyorgy Hajos

Laszlo Denes

Miklos Low

Karoly Lapis

Katalin Gidai

Helga Tudos Nee Feuer

Olga Nyeki

Vince Varro

Laszlo Varga

Lajos Balaspiri

Jozsef Nafradi

Sandor Bajusz

Istvan Horvath

Katalin Csomor

Kalman Szasz

Csaba Lorincz

Lajos Kovacs

Erno Tyihak

Eszter Cholnoky

Attila Juhasz

Laszlo Tvos

Miklos Nagy

Gyorgy Dobo

Gabor Makara

Andras Balazs

Laszlo Otvos

Laszlo Kopper

Laszlo Graf

Tibor Klupp

Kalman Medzihradszky

Kornelia Barabas Nee Borbas

Csilla Vezert Nee Solyom

Agnes Patthy Nee Lukats

Erno Moravcsik

Zsuzsanna Tegyei

Julia Ember

Judit Gyorgyi Nee Edelenyi

Raymund Machovich

Katalin Szeberenyi Nee Szalay

Bertalan Varga

Sara Ronai Nee Lukacs

Zsuzsanna Tegyey

Mihaly Sajgo

Marton Kajtar

Julianna Rochricht

Karoly Simon

Andreas Jeney

Gyorgyne Nyeki Nee Olga Kuprina

Laszlone Szirmai Nee Maria Sarkozi

Maria Skirmai Nee Sarkozi

Rosa Beks

Maria Sz Sarkozi

Andrae Turan

Julianna Rohricht

Antileukemic and immunostimulant peptides

The present invention relates to novel optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives of the formula ##STR1## methods for their preparation, pharmaceutical compositions comprising the said compounds as active ingredients and a method for the anticonvulsive treatment of mammals, especially human beings. The compounds of the formula I have as good activity as diphenyl hydantoine but their toxicity is much lower.

Novel anticonvulsive tetrahydro-1,2,4-oxadiazine-5-thion derivatives and

The invention relates to octapeptides of the formula

Process for the preparation of angiotensin-II analogues substituted in

The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation. The new copolymers comprise the units of the formula I ##STR1## wherein X stands for hydrogen or methyl and Y is hydrogen, units of the formula III ##STR2## optionally units of the formula II ##STR3## wherein Z' is hydrogen, and chain terminating units, formed from the units of the formulae I, III and optionally II under the conditions of copolymerization, in a statistical arrangement, and the pharmaceutically acceptable salts thereof, which contain, in addition to the above chain-members, units of the formulae IV and/or V ##STR4## wherein A is a cation/ satisfactorily replace the organogenic heparin, or give a synergistic combination with that,

Pharmaceutically active copolymers, process for their preparation and

Peptides affecting the immune regulation selected from the following group:

Peptides affecting the immune regulation and a process for their

A tranquillo-sedative substituted 1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one of the formula (I), ##STR1## wherein R.sub.1 is halogen or nitro,

Tranquillo-sedative benzodiazepine derivatives

New octapeptides of the general formula (I),

Angiotensin-II analogues with antagonizing effects, containing an ester

The invention relates to new peptide derivatives which act on the central nervous system and correspond to the general formula (I),

Tripeptides acting on the central nervous system and a process for the

The invention relates to a process for the preparation of a biologically active substance, which can be isolated from normal white blood cells and is capable of inhibiting the proliferation of normal and leukemic myeloid cells selectively. The substance obtained is a peptide, which has an amino acid composition of Tau.sub.1, Asx.sub.1, Ser.sub.2, Thr.sub.1, Glx.sub.3, Gly.sub.2, Ala.sub.1, (PO.sub.4).sub.1.sup.2-, a negative charge at pH 6.5, an electrophoretic mobility of -0.55 to -0.65 related to aspartic acid, has no charge at pH 1.9, has a mobility of about 0.26 related to .epsilon.-DNP-lysine and gives a positive chloro-toluidine reaction.

Process for the preparation of a biologically active substance for

The invention relates to new tetrahydro-1,2,4-oxadiazin-5-one derivatives having a CNS activity. More particularly, the invention concerns new N.sup.4 -substituted tetrahydro-1,2,4-oxadiazin-5-ones of the formula (1) ##STR1## wherein R.sup.2 is benzyloxycarbonyl or alkylcarbonyl containing 1 to 4 carbon atoms in the alkyl moiety, preferably acetyl;

N4-Substituted tetrahydro-1,2,4-oxadiazin-5-one derivatives having

New angiotensin-II analogues of the general formula (I),

Angiotensin-II analogues with antagonizing effects, containing an

The invention relates to new optically active or racemic 5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one derivatives of the general formula (I) ##STR1## wherein R.sup.1 stands for hydrogen, halogen, trifluoromethyl or a nitro group;

5-Phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-ones, and

There are disclosed pharmaceutical compositions comprising at least one cytostatic agent and N.sup..epsilon. -trimethylthyllysin or a pharmaceutically acceptable salt thereof, optionally in association with conventional pharmaceutical carriers and other additives. The new compositions possess a reduced toxicity compared with the cytostatic agents administered alone.

Pharmaceutical compositions and process for the preparation of same

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Budapest, Hungary

Lajos Kisfaludy