Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Biogal Gyogyszergyar

Lajos Ferenczy

Gabor Ambrus

Tibor Lang

Todor Pfliegel

Erzsebet Radvanyi Nee Hegedus

Istvan Ott

Antal Mai

Andras Franko

Gizella Hamar Nee Nemes

A process for the production of aminoglycoside antibiotics using fused protoplasts derived from streptomyces. The cells are precultured in a medium containing sucrose, calcium and magnesium salts. Protoplasts are formed and then fused. The fused protoplasts are regenerate and antibiotic producing ability is screened for. The regenerate cells produced an antibiotic complex of modified composition or demonstrated increased or reduced antibiotic productivity compared to the fusion partners.

Process for the improvement of antibiotic production by in vivo genetic

The invention relates to new synergistic fungicidal compositions comprising a mixture of (a) methyl 2-benzimidazolecarbamate or a precursor thereof, such as methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate and 1,2-bis(3-methoxy-carbonyl-2-thioureido)benzene and (b) 1H-.alpha.-butyl-.alpha.-phenylimidazol-1-yl-propanenitrile.

Synergistic fungicidal compositions

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Szeged, Hungary

Lajos Ferenczy