Auckland Uniservices Limited

Lai Ming Ching

Brian Desmond Palmer

Swarnalatha Akuratiya Gamage

Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR, N or N-oxide; X is CR, N or N-oxide; Y is CR, N or N-oxide; Z is CR, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and Rand Rare as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.

Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy

Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR, N or N-oxide; X is CR, N or N-oxide; Y is CR, N or N-oxide; Z is CR, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and Rand Rare as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer. 

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Auckland, New Zealand

Lai Ming Ching