Tillotts Pharma Ag

Laetitia Von Rochow

Felipe Varum

Roberto Carlos Bravo González

Roberto Bravo

Carsten Markus Füller

Carmen Goetz

Carmen GÖTZ

A method produces a coatable core for a delayed release drug formulation for oral administration, to deliver a drug to the colon. The method involves forming a core containing a drug. An outer layer coating preparation is formed by combining a first aqueous preparation of an enzymatically degradable polymer, which is degradable by colonic bacterial enzymes; a second aqueous preparation of a film-forming enteric polymer having a pH threshold of about pH 6 or above; and an organic anti-tack agent. The core is then coated with the outer layer coating preparation to form an outer layer coated core.

Method of producing a delayed release drug formulation

The present invention relates to a method for preparing immediate and sustained release solid dosage forms, comprising antibodies and functional fragments thereof, by solution/suspension layering, optionally coated with a delayed release coating; the solid dosage forms prepared by the method; and the use of the solid dosage forms in the topical treatment in the gastrointestinal tract of a patient.

Preparation of solid dosage forms comprising antibodies by solution/suspension layering

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Rheinfelden, Switzerland

Laetitia Von Rochow