Dyax Corporation

Laetitia Devy

Clive R Wood

Daniel T Dransfield

Rene Hoet

Robert Charles Ladner

Maria Henderikx

Henk Pieters

Edward Hirsch Cohen

David Buckler

Sonia Schoonbroodt

Nicholas Frans

Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.

Method for treating breast cancer using antibody binding to MMP-14

Provided are methods and compositions for using MMP-14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and osteoporosis.

Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins

Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described.

Metalloproteinase 9 binding proteins

Provided are compositions, methods and kits for quantifying the expression and/or activity of MMP-14 and other biomarkers of cancer, which may be used diagnostically and prognostically, e.g., in patient stratification and evaluation of appropriate therapeutic regimens.

Evaluating MMP expression in patient stratification and other therapeutic, diagnostic and prognostic methods for cancer

Proteins that bind to matrix metalloproteinase 12 and methods of using such proteins are described.

Metalloproteinase-12 specific monoclonal antibody

Metalloproteinase binding proteins

Proteins that bind to matrix metalloproteinase 9 and to matrix metalloproteinase 2 and methods of using such proteins are described.

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Somerville, MA, United States of America

Laetitia Devy