Ceskoslovenska Akademie Ved

Ladislav Sprincl

Jiri Vacik

Jinrich Kopecek

Jindrich Kopecek

Drahoslav Lim

Soluble, hydrophilic polymers suitable for medical use and as blood plasma substitutes comprising low molecular weight polymer derived from at least one monomer of an acrylamide type material or a mono-ester of an acrylic type acid and a glycol which is condensed with bifunctional compounds to form a condensation polymer having increased molecular weight and enzymatically cleavable cross-links. The hydrophilic polymer is produced by polymerizing the acrylamide type material or mono-ester mentioned above to form a low molecular weight polymer which is then condensed with a bifunctional compound to form a high molecular weight condensation polymer having enzymatically cleavable cross-links.

Soluble hydrophilic polymers and process for producing the same

Surgical infusion solutions, useful particularly as blood plasma substitutes, comprising physiological solution of polymers or copolymers formed from ethyleneglycol acrylates and methacrylates, acrylamide, methacrylamide and acrylamides and methacrylamides substituted on the nitrogen atom with either one or two lower alkyl radicals and/or one or two hydroxyalkyl or dihydroxyalkyl radicals containing 1 to 6 carbon atoms and mixtures of these polymeric materials dissolved in a physiological solvent therefor. The polymerization or copolymerization is carried out by solution polymerization methods and the polymeric material is precipitated by mixing it in a suitable non-solvent therefor, but which is miscible with the polymerization solvent.

Infusion solutions and method of manufacturing same

Soluble, hydrophilic polymers suitable for medical use and as blood plasma substitutes comprising low molecular weight polymer derived from at least one monomer of an acrylamide type material or a mono-ester of an acrylic type acid and a glycol which is condensed with bifunctional compounds to form a condensation polymer having increased molecular weight and enzymatically cleavable cross-links. The hydrophilic polymer is produced by polymerizing the acrylamide type material or monoester mentioned above to form a low molecular weight polymer which is then condensed with a bifunctional compound to form a high molecular weight condensation polymer having enzymatically cleavable cross-links.

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Prague-Stodulky, Czechoslovakia

Ladislav Sprincl