Ivax Pharmaceuticals S.r.o.

Other

Ladislav Cvak

Alexandr Jegorov

Milan Stuchlik

Pavel Kolesa

Kvetoslava Benesova

Katerina Ondruszova

Roman Bednár

Roman Sobotik

The present disclosure relates to solid state forms of Voclosporin processes for preparation thereof, pharmaceutical compositions thereof and uses thereof for treating lupus nephritis. 

Solid state forms of voclosporin

Provided are new crystalline Forms VIII, IX, XI, XII, XIV, XV, XVI, XVII, and XVIII of cabergoline. Also provided are novel processes for preparation of cabergoline Form I, Form II, Form VII, and amorphous cabergoline.

Polymorphs of cabergoline

The inventors have devised novel approaches for the preparation of flavanolignan compositions of enhanced solubility and substantially free of toxic contaminants. Such novel approaches are based on spray drying or lyophilizing to dry a diluted preparation of flavanolignan. These approaches avoid the use of toxic excipients and or carriers commonly used to precipitate flavanolignan concentrates and thus address the drawbacks of existing methods and compositions.

Increased solubility flavanolignan preparations

Growing community of inventors

Zlatniky, Czechia

Ladislav Cvak