A. H. Robins Company, Incorporated

Whitby Research, Inc.

L Meredith Moses

Gevork Minaskanian

Chandler R Taylor, Jr

Mark C Sleevi

Brian F Kilpatrick

Optically active or racemic compounds represented by the formula ##STR1## where R.sub.2 is OA and R.sub.3 is selected from the group consisting of H and OA; where A is H or is selected from the group consisting of hydrocarbyl radicals comprising between 1 and 3 carbon atoms, as well as ##STR2## with the proviso that when R.sub.3 is OA, then R.sub.2 and R.sub.3 may be bonded together to form the group R.sub.4 is selected from the group consisting of alkyl and aromatic residues having from 1 to 20, preferably from 1 to 12, carbon atoms, for example, alkyl, optionally substituted with aromatic residues, and aromatic residues optionally substituted with alkyl radicals; n is an integer from 1 to 4; R.sub.5 is an unbranched alkyl chain comprising from 1 and 3 carbon atoms or a cyclopropylmethyl radical; R.sub.1 is alkoxy, cycloalkoxy and a cyclic ether of the formula ##STR3## where m is an integer from 3 to 5; with the proviso that when R.sub.1 is alkoxy, then R.sub.3 cannot be H; and pharmaceutically-acceptable salts thereof. These compounds are useful for alleviating Parkinsonism, glaucoma, hyperprolactinemia and for inducing weight loss in mammals.

Substituted 2-aminotetralins

This invention discloses the antianxiety properties of compounds of the formula: ##STR1## wherein n is 3 or 4, R is C.sub.1 -C.sub.4 alkyl or phenyl, and Ar is ##STR2## where Z is selected from H, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkenyloxy or hydroxy.

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Glen Allen, VA, United States of America

L Meredith Moses