Sungkyunkwan University

Sanken Electric Co., Ltd.

Sanken Electric Korea Co., Ltd.

Kyusam Choi

Shinji Aso

Mitsutomo Yoshinaga

Je-Ho Lee

Kyoungsook Park

Eunsuk Lee

Hanju Kang

Jaekuk Yu

A detector compares a drain voltage with a first threshold voltage and outputs a first detection signal. An ON-counter detects a period of time during which current flows in a switching circuit based on the first detection signal, counts the period of time based on a predetermined clock cycle, and outputs an ON-count value. A first comparator receives the ON-count value and an ON-threshold value and outputs a first comparison signal when the ON-count value and the ON-threshold value match. A second comparator receives the ON-count value and a decreased ON threshold value, compares the ON-count value and the decreased ON-threshold value, and outputs a second comparison signal. An ON-mask time adjuster receives the second comparison signal and outputs an ON-threshold value for adjusting a mask time and a decreased ON-threshold value that is less than the ON threshold value.

Switching power supply apparatus

The present invention relates to a novel function of Msx1 protein for inhibiting tumor angiogenesis and metastasis by targeting mTOR (mammalian target of rapamycin) signaling pathway, and for treating a cancer in a subject. Particularly, Msx1 suppresses mTOR through a direct interaction with mTOR, resulting in the inhibition of angiogenesis. The Msx1 significantly suppresses tumor angiogenesis that is necessary for the growth, invasion, and metastasis of solid tumors. Ad-Msx1 can be used to effectively inhibit tumor metastasis by suppressing angiogenesis, tumor cell invasion, and migration.

Agent that inhibits angiogenesis and metastasis targeting mTOR signaling pathway

Growing community of inventors

Seoul, South Korea

Kyusam Choi