Fenwal, Inc.

Baxter International Inc.

Baxalta Gmbh

Other

Baxter Healthcare Sa

Fenwel, Inc

Kyungyoon Min

Benjamin E Kusters

Richard I Brown

Christopher J Wegener

Brian C Case

Daniel R Boggs

Katherine N Radwanski

William Henry Cork, Iii

Samantha M Planas

Walter T Watts

Amit J Patel

Lan T Nguyen

Witold Moskal

Mark Joseph Brierton

Kevin Krause

John T Foley

James Madsen

Robert J Cantu

Thomas Edward Dudar

Gregory G Pieper

Jonathan W Prendergast

Salvatore Manzella, Jr

Steven R Katz

James Laird

Tom Westberg

John W Barry, Jr

Daniel R Lynn

Craig L Sandford

Douglas W Reitz

Bryan Blickhan

Rohit Vishnoi

Tanima Jahan Abedin

Prakash Parayll Mathew

James Darren Roxas

Sindhu Ramachandran

Tat Mui

Shawn F Bairstow

Alexandra Salomon

Marc N Weasler

Julie Griep

Ying-Cheng Lo

Richard L West

Daniel F Bischof

Zahra R Ali

Daryl Richard Calhoun

Alp Akonur

Mark C Weber

Mark J Brierton

James Joseph Ulmes

Julie Moriarty

Christopher Daniel Gassman

Bret M Olson

Tony Nguyen

Christine Larson

John W Barry

Sharon Pokropinski

Michael J Kast

Mark P Sahlin

Thomas Gniadek

Liam C Farrell

Sandra Thom

Fletcher C Belt

William H Cork

Daryl R Calhoun

Brett T Crawley

Alexander Dodge

Laurent Forcioli

Benjamin E E Kusters

Daniel Martin Karlovsky

Christie Larson

Anand Raju

Robert Bronersky

Alan Armer

Robert I Brown

Cheryl Heber

Ying-Chen Lo

Tat C Mui

Tammy Duncan

Francisco M Iii Rausa

Christopher J Wagener

James C Laird

Julie Moriarity

Larry Backes

Systems and methods are provided for separating blood into two or more components for collection of red blood cells, plasma, or both red blood cells and plasma. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit, with the blood being separated into its constituents by the centrifugal separator. Separated plasma may be collected following separation by the centrifugal separator or may first be conveyed from the centrifugal separator into the spinning membrane separator drive unit to separate cellular blood components from the plasma prior to collection of the filtered plasma. The cellular blood components filtered from the plasma may be retained in the circuit as a waste product or may be flushed out of the circuit to a recipient.

Centrifugal separation and collection of red blood cells and plasma

A head-mounted display device for interface with a medical device includes a frame configured to be mounted on a user's head, a display, a wireless transceiver configured to communicate with a network, and a processing circuit. The medical device is configured to perform an invasive procedure on the person. The processing circuit receives a notification message from the medical device. The processing circuit records medical device information in response to receiving the notification message from the medical device.

Head-mounted display device for use in a medical facility

Systems and methods for performing therapeutic plasma exchange are provided. The systems and methods utilize a plasmapheresis device that includes a controller that is configured and/or programmed to monitor the amount plasma collected and initiate delivery of a therapeutic agent.

Therapeutic plasma exchange systems and methods

Fluid separation chambers are provided with a central hub, with generally annular low- and high-G walls extending about the hub to define therebetween a separation channel. A plurality of radial walls extend from the hub to the channel to define an inlet passage and two outlet passages. The low-G wall may include an air drain taper and/or a decreased radius adjacent to an associated outlet passage. The radius of the low-G wall and (optionally) the high-G wall may gradually decrease from an upstream end of the channel to a downstream end for improved separation. A ramp may extend across the channel, with a bottom end positioned adjacent to the bottom end of the channel, where the outlet passages open into the channel. The outlet passage associated with the high-G wall may open into the channel at an upstream end of the ramp or at the upstream end of the channel.

Continuous flow centrifugation chambers

A system for splitting a fluid includes a source support configured to support a source container and a satellite support configured to support a satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller determines a plurality of possible distributions of the fluid between the source container and the satellite container based at least in part on the concentration or amount of said constituent and the combined weight measured by each weight scale, then controls the clamp system to selectively allow and prevent fluid flow from the source container to the satellite container so as to distribute the fluid between the source container and the satellite container according to one of the distributions, with at least one of the possible distributions being an uneven distribution of the fluid.

Automated splitting of a fluid into uneven volumes

Blood donation frequency is optimized by incentive structures uniquely tailored to individual blood donors. An incentive structure may include incentive offers of different values, with each value being based at least in part on the predicted quality of a blood product produced from blood donated by the donor on a particular date. The structure may alternatively or additionally include one or more incentive offers that are each valued based at least in part on the predicted likelihood of the donor having an adverse reaction to a blood donation occurring on a particular date. The structure may alternatively or additionally include one or more incentive offers that are each valued based at least in part on the predicted likelihood of an attempted blood donation by the target donor being deferred on a particular date.

Incentivization of optimal blood donation frequency

Methods and systems for the automated collection of plasma from a donor are disclosed. The methods and systems deliver anticoagulant to whole blood and/or to selected and separated components at selected times to provide a sufficient amount of anticoagulant to the selected components to prevent coagulation and/or flocculation. The methods and systems limit the amount of anticoagulant returned to the donor and maximize the amount of collected plasma. Methods and systems for maximize the collection of IgG based on a measured level of total plasma protein are also disclosed.

Plasmapheresis methods

A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor weight, height and gender. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.

Plasma collection

A system for splitting a fluid includes a source support configured to support a source container of a fluid flow circuit and at least one satellite support, with each satellite support configured to support a different satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller is configured to control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale. The controller is configured to control the clamp system to selectively allow and prevent fluid flow from the source container to each satellite container based at least in part upon the weights measured by each weight scale. Fluid flow continues until the contents of each container have reached a target volume.

Automated splitting of a fluid

A prismatic reflector is provided for incorporation into a centrifugal separation chamber. The prismatic reflector is formed of a light-transmissive material and includes inner and outer walls and first and second end walls. The inner wall is configured to receive light traveling along an initial path and transmit the light to the first end wall, with the first end wall receiving the light transmitted through the inner wall and directing the light toward the second end wall in a direction that is angled with respect to the initial path. The second end wall receives the light from the first end wall and transmits the light out of the prismatic reflector. The initial path of the light may be in a direction toward a rotational axis of the centrifugal separation chamber, with the prismatic reflector redirecting the light into a direction substantially parallel to the rotational axis.

Prismatic reflector for centrifugal separation chamber

Blood from a blood source is drawn into a fluid flow circuit. A mononuclear cell product is separated from the blood, followed by at least a portion of the mononuclear cell product being conveyed into an electroporation device without disconnecting the blood source from the fluid flow circuit. The electroporation device opens pores in a membrane of at least one of the cells of the mononuclear cell product to allow DNA material (which is added to the mononuclear cell product prior to electroporation) to enter and modify the genome of the cell. At least a portion of the modified mononuclear cell product is returned to the blood source. The mononuclear cell product may be washed prior to being conveyed into the electroporation device. The modified mononuclear cell product may be washed after exiting the electroporation device.

Collection, genome editing, and washing of T-cell lymphocytes

Methods and systems for transfusing reduced-volume blood components are disclosed. Previously collected blood components are introduced into a fluid circuit associated with an apparatus that further separates the component into a reduced volume component and supernatant. The reduced-volume blood component is transfused to the patient in need of the component without the risk of circulatory overload.

Systems and methods for volume reduction of blood products prior to transfusion

A plasmapheresis system and a method for operating a plasmapheresis system are provided by which a volume of plasma product (i.e., anticoagulated plasma) so that that the targeted volume of pure plasma in the plasma product is determined based on donor-specific characteristics. In particular, the targeted amount of pure plasma to be collected is based on the weight, or the weight and the height, of the donor. The targeted volume of pure plasma to be collected, TVP, may be a multiple of the donors weight. Alternatively, TVP may be a multiple of the donor's total blood volume, TBV, with the TBV of the donor being determined based on the donor's weight and height. A target volume for the plasma product to be collected, TVPP, is established, and separation of whole blood into a plasma component and a second component continues until the volume of plasma product in a collection container equals TVPP.

Systems and methods for plasma collection

Systems and methods are provided for collecting a platelet product from a fluid including platelets and plasma. Platelet-rich plasma is separated from at least a portion of another constituent of the fluid and then may be further separated into concentrated platelets and platelet-poor plasma, with the concentrated platelets being resuspended. Separated platelets are conveyed through a size exclusion filter and into a platelet storage container. The size exclusion filter is configured to remove platelet clumps and/or particles larger than a platelet from the separated platelets. Subsequently, an additive is conveyed through the size exclusion filter and into the platelet storage container. Conveying additive through the size exclusion filter improves platelet recovery in the platelet product by displacement of separated platelets with the additive and may also break up any platelet clumps that are present in the size exclusion filter.

Systems and methods for platelet filtration using an additive

A system for collecting plasma comprises a separator to separate whole blood from a donor into a plasma product and red blood cells, an anticoagulant line to introduce anticoagulant to the whole blood, a touchscreen, and a controller. The controller is configured to receive donor parameters electronically from a donor management system. The controller is configured to use a target volume for plasma product and/or raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for plasma product and/or raw plasma based on the total donor blood volume. The controller is configured to control the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the red blood cells and to return the red blood cells to the donor.

Systems and methods for optimization of plasma collection volumes

Growing community of inventors

Kildeer, IL, United States of America

Kyungyoon Min