Choongwae Pharma Corporation

Kyung-Yun Jung

Jae Uk Chung

Sang-Hwi Lee

Myoung-Joo Kang

Min-Wook Jeong

Hee-Kyung Jung

Hyun-Ju La

Hoe-Moon Kim

Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

Compounds of reverse turn mimetics and the use thereof

Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic frame-work are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to the use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

Compounds of reverse turn mimetics and the use thereof (2)

Growing community of inventors

Gyeonggi-do, South Korea

Kyung-Yun Jung