Korea Research Institute of Bioscience and Biotechnology

Korea Research Institute of Chemical Technology

Dongguk University Industry-Academic Cooperation Foundation

Anterogen Co. Ltd.

Kyung Sook Chung

Mi Sun Won

Cho Rok Jung

Hyang Sook Yoo

Hwan Mook Kim

Han Oh Park

Kyeong Seok Lee

Seung-Hee Lee

Dong Uk Kim

Bo Kyung Kim

Young Il Yeom

Jung Joon Lee

Hee Gu Lee

Mi Young Son

Eun Young Song

Dong Sup Kim

Sun Woong Kang

Shin Jung Choi

Chang Woo Lee

Kiho Lee

Song Kyu Park

Jung Hwa Lim

Myung Jin Son

Ki Hoon Lee

Hye Mi Lee

Jae Hun Cheong

Min Ho Lee

Young Joo Jang

Ji Won Ahn

Seung Tae Baek

Kwang Lae Hoe

Jeong Hae Choi

Chang Mo Kang

Hyong Bai Kim

Yinglan Jin

Hyun Mi Kang

Kyung Hee Noh

Mi Young Nam

Sang Soo Han

Kyung Sun Heo

Mi Hyung Kim

Jo Young Park

Sang Jo Han

A cell culture vessel according to the present invention is characterized by comprising a first vessel having a stirring member disposed therein, and a second vessel configured to be inserted in the interior of the first vessel and having a hole for allowing a solvent accommodated in the first vessel to pass through the interior thereof, wherein the stirring member is arranged in a recess portion formed in the first vessel.

Cell culture receptacle

The present disclosure provides a biomimetic cell culture apparatus that mimics interactions among organs in a human body. The present disclosure includes a plurality of culture units for culturing cells, a conduit for connecting the plurality of culture units to each other to form a circulating path, a pump unit disposed on the conduit for forming a flow in culture medium such that the culture medium circulates through the plurality of culture units, and an agitating module for agitating the plurality of culture units.

Biomimetic cell culture apparatus and cell culture system comprising the same

The present invention relates to: a composition for detecting a marker for detecting the proliferation capacity or treatment capacity of adipose-derived stem cells cultured in a medium containing epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF); and a detection method.

Marker for detecting proliferation and treatment capacities of adipose-derived stem cell cultured in medium containing EGF or BFGF, and use thereof

A method comprising transformingwith a deletion cassette, constructed by four-round serial PCR, block PCR or total gene synthesis, containing a homologous recombination site is provided for preparing gene-targeted heterozygous deletion. Also provided are gene-targeted hetero2ygous deletionmutants prepared by the method, and a library of gene-targeted heterozygous deletionmutants. Further, the library is useful in constructing a method and a kit for screening a drug's modes of action.

[object Object]

Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

G protein coupled receptor protein and use thereof

The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.

Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient

Growing community of inventors

Daejeon, South Korea

Kyung Sook Chung