Industry-University Cooperation Foundation Hanyang University

Industry-university Cooperation Foundation

Samsung Sds Co., Ltd.

Kyung Ho Cho

Pil Seok Chae

Chul Ho Choi

Hee Jong Kim

Ho Kyung Yoo

Jung Hee Yoon

Hyong Gook Kim

Moo Young Cho

Jeong Heon Kim

In Yong Jang

Yeong Ho Lee

Tae Jin Hwang

The present invention relates to a xylene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing or crystallizing a membrane protein using the same. By using the xylene-based compound according to the present invention, a membrane protein may be stably stored in an aqueous solution for a long time, and may be applied in functional and structural analyses. The structural and functional analysis of the membrane protein is one of the fields of highest interest in biology and chemistry, and the xylene-based compound according to the present invention can be applied in research on protein structure that is closely related to development of a new drug.

Xylene-based amphiphilic compound and use thereof

The present invention relates to a mesitylene-cored amphiphile, a method of preparing the same and a method of extraction, solubilization, stabilization, crystallization or analysis of a membrane protein using the same. When a mesitylene-cored compound according to the present invention is used, membrane proteins can be stored in a stable conformation for a long time in an aqueous solution in comparison with conventional compounds, by which the membrane proteins are usable in both functional and structural analyses thereof. The functional and structural analyses of membrane proteins are one of the fields that are most spotlighted in current biology and chemistry. The present invention can be used to research on a protein structure closely related to new drug development.

Mesitylene-cored amphiphiles and uses thereof

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Seoul, South Korea

Kyung Ho Cho