Samyang Biopharmaceuticals Corporation

Samyang Biopharmaceutical Corporation

Kyung-Hee Kim

Chaul-Min Pai

Hye-Jung Lim

Jun-Seok Hwang

Su-Jong Hwang

Sang-Yeob Park

Hyun-Ki Lee

Disclosed are a controlled release pharmaceutical composition, comprising a melt-extruded pellet including a water-insoluble ammonium methacrylate copolymer, a polyvinyl acetate, and an active ingredient; and a polymer coating layer including a water-insoluble ammonium methacrylate copolymer formed on the surface of the pellet, and an oral formulation including the pharmaceutical composition.

Melt-extruded release controlled pharmaceutical composition and oral dosage form comprising the same

A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.

Poorly soluble drug containing microspheres with improved bioavailability and method of preparing the same

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Daejeon, South Korea

Kyung-Hee Kim