Korea Atomic Energy Research Institute

Kyung Bae Park

Sang Hyun Park

Sun Ju Choi

Byung Chul Shin

Sang Mu Choi

Hui Jeong Gwon

Beom Su Jang

Woong Woo Park

Kwang Hee Han

Young Don Hong

Deuk-Gun Park

Yeong-Garp Cho

Jong Doo Lee

An apparatus for producing magnetized water. The apparatus comprises a plurality of magnet bars arranged in a radial manner, in which each magnet bar is structured such that a plurality of neodymium based permanent magnets is stacked in a stainless steel pipe in a manner such that like poles of the permanent magnets face each other. Thanks to this structure, the apparatus has a large contact area between the magnetic field and water flowing through the apparatus, thereby activating water by changing the structure of water. In more detail, the apparatus comprises a magnet bunch including a plurality of fixed magnet bars, a plurality of standard magnet bars, an upper plate disposed on upper ends of the fixed and standard magnet bars, a lower plate disposed on lower ends of the fixed and standard magnet bars, and a spacing plate disposed between the upper and lower plates; a housing having a cylindrical main body for enclosing the magnet bunch therein, an opening in an upper end portion thereof, and a lower part having a funnel shape and a liquid passage; and a coverfor covering the opening of the housing, the cover being coupled to the housing in a detachable manner and having a funnel shape and a liquid passage.

Apparatus for producing magnetized water

A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.

Method for labelling technetium or rhenium using borohydride exchange resin

The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER). The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2&#x2dc;14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.

Method for the preparation of technetium or rhenium complex for radiopharmaceuticals

Disclosed is a method of preparing a rhenium complex by use of a borohydride exchange resin, including dissolving perrhenic acid in a solution containing ethylenediamine tetraacetate, mannitol and stannous chloride to obtain a perrhenic acid solution (step 1), which is then mixed with disulfide in the presence of a borohydride exchange resin and reacts at room temperature, to obtain a rhenium complex (step 2). The preparation method of the current invention is characterized in that rhenium is reduced to have a desired oxidation number through the dissolving of the step 1, whereby the reaction of the step 2 can occur at room temperature. In addition, use of the borohydride exchange resin as a reducing agent results in direct formation of the rhenium complex of sulfide from disulfide, without the need of synthesis of thiol-protected S-precursor. Therefore, radioactive pharmaceuticals having high values can be economically and efficiently produced.

Method of preparing rhenium complex using borohydride exchange resin

The present invention relates to a radioactive balloon for angioplasty which is combined with a flexible film containing radionuclides and process for preparation thereof. A balloon dilatation catheter system containing the radioactive balloon can be used in transluminal coronary angioplasty, expanding blood vessel and facilitating the blood flow so as to prevent the proliferation of smooth muscle cell and vascular restenosis efficiently.

Radioactive balloon for dilation catheter system and process for preparation thereof

The present invention relates to a radioactive stent surrounded with a flexible sleeve containing radionuclides and processes for preparation thereof, which can be used to treat arteriosclerosis, hepatobiliary duct cancer and esophageal cancer efficiently since the stent prevents the restenosis of coronary artery and the penetration of cancer cells into lumen.

Growing community of inventors

Daejeon, South Korea

Kyung Bae Park