Legochem Biosciences, Inc.

Kyuman Oh

Sunyoung Kim

Jongun Cho

Taekyo Park

Doohwan Jung

Yun-Hee Park

Yongzu Kim

Sungho Woo

Hyangsook Lee

Youngun Kim

Hyunjin Kwon

Yunseo Chung

Sun Young Kim

Yong Zu Kim

Chul Soon Park

Sung Ho Woo

Hyang Sook Lee

Tae Kyo Park

Sang Eun Chae

Young Lag Cho

Hye Jin Heo

Hong Bum Lee

Sung Yoon Baek

Hyun Jin Kwon

Dae Hyuck Kang

Joung Yul Yun

Young Jae Yang

The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).

Antibody-active agent conjugates and methods of use

Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group. In Formula 1, R and Q are the same as defined in the detailed description. In addition, disclosed is a pharmaceutical composition for an antibiotic which includes the novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against Gram-positive and Gram-negative bacteria and thus may be effectively used as antibiotics.

Oxazolidinone derivative and medical composition containing same

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Daejeon, South Korea

Kyuman Oh