Wisconsin Alumni Research Foundation

National Institutes of Health, a Component of the US Dept. of Health & Human Services

University of Chicago

Sogang University Research Foundation

National Institutes of Health

University of Leiden

U.S. Government Nih Division of Extramural Inventions and Technology Resources

Kyubong Jo

David Charles Schwartz

Juan Jose De Pablo

Konstantinos Dimitrios Potamousis

Kristy Leigh Kounovsky-Shafer

Theo Odijk

Juan Pablo Hernandez-Ortiz

Dalia M Dhingra

Jihyun Park

Seonghyun Lee

Eunji Shin

Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.

System and method for en masse patterning of molecule structures

The present invention relates to a composition for DNA sequence analysis and a method for DNA sequence analysis, the method comprising treating a sample with the composition. The composition of the present invention can attain efficient optical identification at a single-DNA molecule level by linking both an A/T-specific DNA-binder agent and an A/T-non-specific complementary DNA-binder agent to DNA, and thus can be helpfully used in studying chromosomal organization of genomes, protein immunolocalization, and the like.

Flourescent protein composition for DNA sequence analysis and method for DNA sequence analysis using same

Methods are provided for tagging, characterizing and sorting double-stranded biomolecules while maintaining the integrity of the biomolecules.

Method of DNA analysis using micro/nanochannel

Growing community of inventors

Seoul, South Korea

Kyubong Jo