Lg Life Sciences, Limited

Kyu Woong Lee

Jae Hoon Lee

Hyun Ik Shin

Hyeong Wook Choi

Hee Bong Lee

Bong Chan Kim

Chang-Seok Lee

Hyeon Joo Yim

Ki Sook Park

Changhee Min

Kyu Young Kim

Kyoung-Hee Kim

Wan Su Park

Tae Ho Heo

Sung-Hack Lee

Jaeick Lee

Ji Eun An

The present invention relates to a novel method for preparing a compound of formula (2) as the intermediate, which can be effectively used for preparation of a compound of formula (1) exhibiting good inhibitory activity against dipeptidyl peptidase IV enzyme.

Production method of intermediate compound for synthesizing medicament

Disclosed herein are novel compounds of Formula (1) as defined in the specification having excellent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions comprising the same as an active agent.

Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent

The present invention relates to an isoxazoline derivative having the cyclic carboxylic acid hemiketal moiety of formula (1) for use as caspase inhibitor, a process for preparing it, and a pharmaceutical composition comprising it.

Isoxazoline derivative and novel process for its preparation

The present invention relates to a novel process for the production of 3-amino-5-fluoro-4-dialkoxypentanoic acid ester used in the precursor of 3-amino-5-fluoro-4-oxopentanoic acid, represented by the following formula (I): wherein R1 and R2 are as defined in the Description. 

Process for preparing 3-amino-5-fluoro-4-dialkoxypentanoic acid ester

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Daejeon, South Korea

Kyu Woong Lee