Leland Stanford Junior University

Korea Research Institute of Bioscience and Biotechnology

Daegu Gyeongbuk Institute of Science and Technology

Daegu-Gyeongbuk Medical Innovation Foundation

Kyu-Sun Lee

Sang Bum Kim

Hwan Geun Choi

So Young Kim

Jung Beom Son

Nam Doo Kim

Bingwei Lu

Yi Kyung Ko

Seock Yong Kang

Seungyeon Lee

Eunhwa Ko

Sun-Hwa Lee

Jin-Hee Park

Dayea Kim

Hee Yoon Ryu

Sun Joo Lee

Sungchan Cho

Joong-heui Cho

Miri Choi

Ja Wook Koo

Hyang-Sook Hoe

Kweon Yu

The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases

Methods and compositions are provided for treating an individual having cancer. Aspects of the methods include administering to the individual an inhibitor of a non-canonical Notch signaling pathway gene in an amount effective to treat the cancer. Also provided are reagents, devices and kits thereof that find use in practicing the subject methods.

Targeting a non-canonical notch signaling pathway for cancer treatment

Growing community of inventors

Daejeon, South Korea

Kyu-Sun Lee