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Newtree Co., Ltd.

Newtree Industry Co., Ltd.

Kyu-Lee Han

Jae-Kwan Hwang

Jae-Young Lee

Jeong-Hwan Kim

Do Un Kim

Heechul Chung

Jong-hee Sohn

Jae Youn Chung

Jae-Youn Chung

Hee-Chul Chung

Do-Un Kim

Ah-Jin Kim

Jeong-Han Choo

The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE, COX-2 and TNF-&#x3b1; and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or aextract will be highly useful for the treatment or prevention of an inflammatory disease.

Use of lignan compounds for treating or preventing inflammatory disease

Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)-mediated diseases, such as diabetes mellitus, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I): or a pharmaceutically acceptable salt thereof.

Method for treating conditions mediated by PPAR using macelignan

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Seoul, South Korea

Kyu-Lee Han