Kyungpook National University Industry-Academic Cooperation Foundation

Seoul National University

Kyoungho Suk

Youngpyo Nam

Sanghee Lee

Jongmin Park

Seung Bum Park

Ja Young Koo

Myungjin Jo

Gyun Jee Song

Donghyun Lim

There is provided a composition for treating a neuroinflammatory disease comprising a N-carbamoylated urethane compound which has an effect of inhibiting the activity of microglia or astrocytes and the production of nitric oxide (NO) and TNF-&#x3b1;, and suppressing the expression of IL-1&#x3b2; And iNOS genes. There is also provide a method for treating a neuroinflammatory disease, the method comprising the step of administering a N-carbamoylated urethane compound. Due to its above mentioned effects, the N-carbamoylated urethane compound according to the present invention can be useful for the treatment of neuroinflammatory diseases.

N-carbamoylated urethane for treating a neuroinflammatory disease

Disclosed herein is an anti-inflammatory pharmaceutical composition comprising a benzopyranyl tetracycle compound represented by Chemical Formula 1 as an active ingredient. The compound exhibits excellent anti-inflammatory activity by perturbing the post-translational modification of the inflammation mediator HMGB, and thus finds applications in pharmaceutical compositions superior in the treatment or prevention of inflammation-related diseases.

Anti-inflammatory pharmaceutical composition comprising benzopyranyl tetracycles

Growing community of inventors

Daegu, South Korea

Kyoungho Suk