Samsung Fine Chemicals Co., Ltd.

Chiroad Incorporate

Kyoung Rok Roh

Dae Il Hwang

Young Mi Park

Hosung Yu

Jongpil Chun

Yik-haeng Cho

Won Jang Lee

Dae Hwang, Ii

Dae Yon Lee

Kyung-Il Kim

Kyung Il Kim

Ji Sang Yoo

Ho Sung Yu

Jong Won Jang

Jung Hwan Lee

A method of preparing optically pure (S)-3-hydroxypyrrolidine is disclosed. The present invention provides a method of economically and industrially preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising introducing an amine protecting group by using optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, reducing a carboxylic acid group into a primary alcohol, removing the amine protecting group to form an amine salt, halogenating the primary alcohol, and amine cyclization; and through a simple purification process, i.e., distillation under reduced pressure. As another method, the present invention provides a method of preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising esterifying optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, lactam cyclization, and reduction.

Synthetic method of optically pure (S)-3-hydroxypyrrolidine

Process for preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone

Process for preparing(R)-4-cyano-3-hydroxybutyric acid ester

A process for the preparation of chiral (S)-2,3-disubstituted-1-propylamine derivatives, in which a carbonyl group of (S) 3,4-disubstituted-1-butanecarbonyl derivatives is converted to an amine group, and the conversion reaction is performed through Curtius rearrangement or Hoffman rearrangement.

Process for preparing chiral (s)-2,3-disubstituted-1-propylamine derivatives

Continuous process for preparing optically pure (s)-3,4-dihydroxybutyric acid derivatives

Continuous process for preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone

Process for preparing optically pure(S)-3,4-dihydroxybutyric acid derivatives

The present invention relates to a process for preparing optically pure (S)-3-hydroxy-.gamma.-butyrolactone expressed by the following Formula 1 and more particularly, to a process that enables preparing optically pure (S)-3-hydroxy-.gamma.-butyrolactone economically in large quantities, by:

Process for preparing optically pure (S)-3-hydroxy-.gamma.-butyrolactone

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Daejeon, South Korea

Kyoung Rok Roh