Korea Research Institute of Bioscience and Biotechnology

Korea Research Institute of Bioscience

Kyoung-Ran Im

Yang-Kyu Choi

Tae-Sook Jeong

Woo-Song Lee

Og-Sung Moon

Hyoung-Chin Kim

Jun-Seock Son

Ju-Ryoung Kim

So-Jin An

Ki-Chang Jang

A method for treating cardiovascular disease, including hyperlipidemia and atherosclerosis, using abietane diterpenoid compound or terpenoid compound isolated fromas an effective ingredient. The abietane diterpenoid compound or terpenoid compound isolated fromnot only excellently inhibits oxidation of low-density lipoprotein (LDL), but also effectively inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity.

Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

The present invention relates to a method for treating a cardiovascular disease, such as hyperlipidemia or atherosclerosis, with a pharmaceutically effective amount of an extract ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.extracts, abietane diterpenoid compound, or terpenoid compound isolated from the extracts were prepared by extractingleaves, stems, or seeds with water, alcohol, or mixed solution of water and alcohol, which is further fractionized with n-hexane, chloroform and etheyl acetate in that order. Further, the present invention provides a method for inhibiting an oxidation of low-density lipoprotein (LDL) and inhibiting Acyl-CoA:cholesterol acyltransferase (ACAT) using an extract ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.

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The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further,extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.

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Taejeon-si, South Korea

Kyoung-Ran Im