Cheil Foods & Chemicals, Inc.

Kyoung E Choi

Sung Yong Park

Choong S Kim

Sung Kwang Cho

Je Hak Kim

Yeo H Yoon

Seung Ho An

Yang S Ahn

Chun S Lyu

Rok L Yun

Koun H Lee

Novel semi-synthetic cephalosporin derivatives having a fused pyridiniummethyl at 3-position of the cephem nucleus, pharmaceutically acceptable salts, physiologically hydrolizable esters or solvates thereof are disclosed. Also disclosed is a process for preparing the cephalosporin derivatives which comprises introducing a fused pyridiniummethyl substituent at 3-position of 7-.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-ca rboxylic acid derivatives. The compounds of the present invention show potent antibacterial activities and a broad spectrum against both gram-positive and gram-negative bacteria.

3-fused pyridiniummethyl cephalosporins

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Seoul, South Korea

Kyoung E Choi