Seikagaku Corporation

Seikagaku Kogyo Co. Ltd.

Kyosuke Miyazaki

Hiroyuki Masuda

Hiroshi Fujita

Yasuhiro Kurahashi

Sadaaki Iwanaga

Katsukiyo Sakurai

Shigeyuki Wakitani

Takanori Nakamura

Masashi Nawata

Motonori Ohno

An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like. The present invention as a means for achieving the object provides a method of detecting articular cartilage degeneration or damage which cannot be detected in a radiograph, by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like. Further, the present invention provides a method of evaluating the rate of progression of articular cartilage degeneration or damage by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.

Method of detecting articular cartilage degeneration or damage

A glycosaminoglycan-modified protein wherein an amino group of a protein is bound to an aldehyde group, which has been formed by reducing and partially oxidizing the reducing terminal sugar moiety of a glycosaminoglycan, which has a high stability in vivo and can retain physiological activity of the protein for a prolonged period of time.

Glycosaminoglycan-modified protein

Lipopolysaccharide-binding polypeptide

Growing community of inventors

Tokyo, Japan

Kyosuke Miyazaki