University of Pittsburgh

Kyongtae Ty Bae

Tao Jin

Wen Ling

Sung-Hong Park

A method of measuring a tissue parameter such as proteoglycan content and other relevant tissue parameters, e.g. tissue pH, in a tissue or an organ of a subject includes generating first and second frequency magnetic resonance data using Tscans at different frequencies, wherein the frequencies are symmetric. The method also includes combining the first frequency magnetic resonance data and the second frequency magnetic resonance data to remove a number of contributions from a number of relaxation mechanisms other than chemical exchange, thereby obtaining chemical exchange-specific magnetic resonance data indicative of the tissue parameter in the tissue or the organ. The chemical exchange-specific magnetic resonance data may be used to measure the proteoglycan content in the tissue or organ.

Method and system for monitoring a tissue parameter such as proteoglycan content by magnetic resonance imaging

A dual-echo sequence technique provided herein empowers simultaneous acquisition of both TOF MRA and BOLD MRV in a single MR acquisition. By this approach, an echo-specific K-space ordering scheme permits the adjustment of the scan parameters that are compatible for each of the MRA and MRV. The image quality in the MRA and MRV acquired by this compatible dual-echo arteriovenography (CODEA) technique is comparable to that for conventional, single-echo MRA and MRV. When the technique is integrated with MOTSA, seamless vascular connectivity is achieved in both MRA and MRV over a large area of brain anatomy. The technique will facilitate routine clinical acquisition and application of dual-echo MRA and MRV, as both MRA and MRV can be acquired with minimal impact on the image quality and without adversely affecting the scan throughput.

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Pittsburgh, PA, United States of America

Kyongtae Ty Bae