Suntory Limited

Kyoko Kuroda

Hiroshi Nagai

Terumi Nakajima

Hiroyuki Minakata

Eiko Iwakoshi

A novel peptide found as gonadotropin-releasing hormone (GnRH) in octopuses, a member of mollusks. The structure and the activities of the peptide have been unraveled. The peptide finds use as a reagent used in the studies of correlations between the structure and the activities of GnRH and the information processing mechanisms of the nervous systems in higher animals. It can also serve as a base compound in the development of pesticides and drugs. The peptide has the GnRH activity and has the following amino acid sequence (I):&#x3c;Glu-Zaa-Zaa-His-Zaa-Ser-Zaa-Zaa-Zaa-Zaa-Pro-Gly-NH(SEQ ID NO: 7) &#x2003;&#x2003;(I)wherein &#x3c;Glu represents pyroglutamic acid and Zaa represents any amino acid. Specifically, the peptide has the following amino acid sequence (1):&#x3c;Glu-Asn-Tyr-His-Phe-Ser-Asn-Gly-Trp-His-Pro-Gly-NH(SEQ ID NO: 1) &#x2003;&#x2003;(1)wherein &#x3c;Glu represents pyroglutamic acid.

Gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same

Tachykinin peptide isolated and purified from the posterior salivary gland of the mollusk. The tachykinin peptide provides a new approach for developing medicaments and pesticides through studies on the structural activity correlation at the molecular level, is characterized by:

Tachykinin peptides, precursor peptides thereof and genes encoding the same

Hemolytic proteins offer new approaches to drug development. The hemolytic proteins are obtained from a nematocyst of. Alternatively, the proteins may be recovered from cultured cells transfected with the sequence encoding the hemolytic protein of

Proteins having hemolytic activity and genes encoding the protein

Novel proteins having hemolytic activity giving the new approach of development of the drugs, and having the following property are provided:

Growing community of inventors

Kyoto, Japan

Kyoko Kuroda