Hitachi, Ltd.

Hitachi-high-technologies Corporation

Roche Diagnostics Operations, Inc.

Hitachi High-tech Corporation

Hitcahi, Ltd.

Ihu Mediterranee Infection

Kyoko Imai

Yasushi Nomura

Kazumichi Imai

Shigeki Matsubara

Yukie Tokiwa

Taku Sakazume

Toshiro Saito

Tomonori Mimura

Muneo Maeshima

Satoshi Takahashi

Kenta Imai

Masahiko Ando

Takashi Irie

Ryuji Tao

Hiroshi Umetsu

Isao Shindo

Koshin Hamasaki

Hiroshi Hashimoto

Hajime Betsui

Kahei Shiraishi

Kantaro Suzuki

Noriko Maeda

Chihiro Uematsu

Christoph Boehm

Naoshi Itabashi

Yoshimitsu Yanagawa

Yoshimitsu Takagi

Juergen Spinke

Toshinari Sakurai

Makiko Takahashi

Itaru Yanagi

Tadashi Ohishi

Thorsten Brueckner

Terumi Tamura

Yuusuke Oominami

Noriko Iizumi

Naoto Oki

Ryuichiro Kodama

Yasunori Shoji

Kenichi Takahashi

Lotterer Siegfried

Krause Friedemann

Fumitoshi Hamasaki

Masumi Kawase

Junko Momose

Tomoko Tomiyama

Yoshinori Negishi

Didier Raoult

Jacques Bou Khalil

When a sample of biological origin in an aqueous solution is used as the measurement medium in analysis using an electrochemical process, and a voltage of +1.2 V or greater (with saturated silver-silver chloride electrode potential as a reference) is applied, there are instances in which bubbles are observed to be produced within the flow cell, due to an electrolysis reaction deriving from the measurement buffer. There is a possibility that bubbles produced on the electrode will cover the electrode surface, reducing the effective surface area of the electrode. Also, the distribution of magnetic particles captured on the electrode will be disturbed by the gas produced thereby, lowering the reproducibility of the results of the analysis. Deaeration of the measurement medium prior to introduction of the measurement medium into the detector minimizes the effects of bubble production in degrading the analytical capability makes it possible to carry out highly sensitive electrochemical analysis.

Automatic analysis apparatus

A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower. Nucleic acids can be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.

Method and apparatus for nucleic acid analysis

A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid. The reservoir chamber has a fluid outlet. The cartridge further comprises a controllable dispenser component for dispensing a dispensing volume of the fluid from the reservoir chamber. The dispenser component is connected to the fluid outlet of the reservoir. The cartridge further comprises a single compressible fluid pump with a single elastic pumping element and a conduit extending from the fluid pump towards the fluid outlet. The fluid pump discharges a mixing volume of the fluid from the conduit into the reservoir chamber upon compression of the elastic pumping element. The mixing volume depends on the degree of compression of the elastic pumping element. The fluid pump sucks in the mixing volume from the reservoir into the conduit upon decompression of the elastic pumping element.

Cartridge for dispensing a fluid, automatic analyzer and method of analyzing a biological sample

An object of the present invention is to provide a highly sensitive immunoanalysis method and analysis apparatus. The invention relates to an analysis method and an analysis apparatus which are constituted in such a way that a component to be measured is reacted with capture component specifically reacting thereto and the reactant is labeled when the component to be measured is present and which are characterized by analyzing the component to be measured with single-molecule sensitivity and resolution by arranging the labeled reactant in a spatially separated certain position and detecting the label of the labeled reactant.

Immunoanalysis method and immunoanalysis device

The method for analyzing biomolecules, includes the steps of: immobilizing biomolecules to be analyzed on surfaces of magnetic microparticles; reacting labeled probe molecules with the biomolecules to be analyzed; collecting and immobilizing the microparticles on a support substrate; and measuring a label on the support substrate. Since single-molecule immobilized magnetic microparticles are used in the present invention, the number of biomolecules can be counted, and since hybridization and an antigen-antibody reaction are performed with the microparticles having biomolecules immobilized thereon dispersed, the reaction can be rapidly performed. Further, the type and the abundance of biomolecules of interest can be determined at a single molecular level, so as to evaluate, in particular, the absolute concentration of biomolecules.

Method for analyzing biomolecules and biomolecule analyzer

The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors.

Biomolecule detection method, biomolecule detection device and analysis device

An automatic analyzer includes a storage unit for storing operation information information about usage histories of expendable supplies provided for the analysis, and an analysis-ID control unit giving an ID to the analysis, the analysis ID being used as information for identifying the analysis to derive a calibration curve. Data stored in the storage unit is organized along the same time axis both in the order of samples subjected to the analysis and inspection, and in the order of analysis items, so that the data is output in a total data display area. The data is organized from the viewpoint of an analysis process of an analysis item of each sample. By use of information used to identify an influence range based on a kind of an abnormal state, which is stored beforehand, a judgment is made as to whether or not it is necessary to perform reinspection.

Automatic analyzer

Nucleic acid analysis apparatus includes a plurality of temperature adjustment apparatuses, a rotating mechanism, a delivery base and an ejection base, a delivery drive mechanism, an ejection drive mechanism, and a detection apparatus. The rotating mechanism can include a rotating shaft and a plurality of pressing portions that rotate around the rotating shaft. The reaction plate assembly can move over the temperature adjustment apparatuses along the circumferential direction in a state of being pressed onto the temperature adjustment apparatuses by the pressing portions. The delivery drive mechanism can cause the reaction plate assembly to be moved radially inward and delivered between the pressing portions and temperature adjustment apparatuses. The ejection drive mechanism can cause the reaction plate assembly to be moved radially outward and ejected from between the pressing portions and temperature adjustment apparatuses onto the ejection base. Reaction plates, reaction plate assemblies, and nucleic acid analysis apparatuses are provided.

Reaction plate assembly, reaction plate and nucleic acid analysis device

An automatic analyzer and an automatic analyzing system to identify samples and reagents used in the analyzer and members used in measurement of at least two objects in common: system reagents or buffer solution; sensor parts; probes; nozzles; chips; dispensing cups; tubes; ISE electrodes; detectors; deionized water; and waste, and to unify management of identification information thereof and a measurement result.

A method of pipetting an accurate quantity of liquid comprising the steps of drawing water into a pipetting chip () from a liquid container (), drawing air into said tip first slowly at a first rate and then quickly at a second rate to turn said drawn water into a mist of drops in said tip () and increase the relative humidity of the air in said tip (), waiting a preset time period, and drawing a tested liquid into said tip (). This makes the quantity of vapor of the tested liquid in said tip () very small and constant and thus the accurate quantity of tested liquid can be pipetted.

Liquid dispensing method and device

In an automatic analyzer, necessary setup works are displayed prior to analysis operation. The present invention can realize an automatic analyzer which can be used by an inexperienced operator to execute all necessary setup works. A maintenance button, data erase button, reagent status button, reagent prime button, calibration button and QC button are displayed on a system viewing screen displayed on an operation part. The display colors of the maintenance button or the like are changed (for example, the display color is changed to red, yellow or the like) in response to the status of the automatic analyzer in order to recognize necessary setup works prior to analysis operation for an operator.

Sample sampling to an analysis apparatusorfor analyzing a biochemical analysis item is performed by a pipetting deviceorwhich uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatusorfor analyzing an immune analysis item is performed by a pipetting deviceorwhich uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.

Handling method of body fluid sample and analysis apparatus using the same

An automatic analysis apparatus containing a plurality of measurement channels used to measure reaction occurred in a reaction container into which both a reagent and a sample are entered, is arranged by employing: a data processing unit for producing calibration information, first quality control information, and second quality control information; the calibration information every measurement channel being produced based upon calibration data obtained by measuring a calibration sample, the first quality control information related to a quality for each of the measurement channels being produced based upon measurement data acquired by measuring a quality controlling sample by the respective measurement channels, and also the second quality control information related to an entire quality of the plural measurement channels being produced based upon the measurement data; and a display unit for simultaneously displaying the calibration information, the first quality control information, and the second quality control information given by the data processing unit on a single screen.

Automatic analysis apparatus, managing apparatus for analysis apparatus, and program product for managing analysis apparatus

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Hitachinaka, Japan

Kyoko Imai