Shionogi Company Limited

Kyoji Minami

Yoshio Hamashima

Koji Ishikura

Yusuke Suzuki

Kyozo Kawata

Toyohiko Takeda

Teruo Sakamoto

Masanori Tujikawa

Tadatoshi Kubota

Teruji Tsuji

Tadashi Yoshida

Tetsuo Okada

Hiroshi Onoue

Hiroyuki Ishitobi

An antibacterial 3-vic-dihydroxyaroylmethylpyridiniothiomethyl cephalosporin (I) and its salts represented by the following formula: ##STR1## (wherein, R.sup.1 is amino group or acylamino; R.sup.2 is hydrogen or methoxy; R.sup.3 is hydrogen atom or substituent; R.sup.4 is vic-dihydroxyaryl; R.sup.5 is straight or branched lower alkylene; R.sup.6 is hydrogen, a carboxy-protecting group or combined with Y a negative charge; X is --O--, --S-- or sulfinyl; and Y is a counter-ion of pyridinio or combined with R.sup.6 a negative charge), a disinfecting and treating method of bacterial infection using it, and synthetic methods thereof are provided.

Phenacylpyridiniothiocephalosporins

An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule and sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.

Gelatin hard capsule containing crystalline hydrate of oral cephalosporin

Method for preparing crystalline hydrate of oral celphalosporin and its

An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.

Crystalline hydrate of oral cephalosporin and its composition

An oral antibacterial, 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-alkenoylamino]-3-cephem-4-carboxylic acid pharmaceutically acceptable ester represented by the following formula: ##STR1## (wherein R is amino or protected amino,

Alkeneamidocephalosporin esters

An antibacterial 3-(alkylcarbamoyloxymethyl)-3-cephem-4-carboxylic acid or its derivatives represented by the following formula ##STR1## (wherein R is hydrogen or an amino-protecting group,

Alkylcarbamoyloxymethylcephem compounds

Antibacterial 7.beta.-(oxo-saturated heterocyclic carbonamido)-3-cephem-4-carboxylic acid derivatives of the formula: ##STR1## (wherein R is hydrogen or methoxy; R.sup.1 is hydrogen or a nucleophilic group; R.sup.2 is hydrogen, light metal, or a carboxy protecting group; X is oxygen, sulfur, sulfinyl, or sulfonyl; Y is alkylene containing one or more hetero atoms; and Z is hydrogen or a substituent).

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Nara, Japan

Kyoji Minami