Kyowa Hakko Kirin Co., Limited

Kyowa Hakko Kogyo Co., Ltd.

Kyoichiro Iida

Haruhiko Manabe

Nobumasa Otsubo

Kenji Uchida

Fumio Suzuki

Yoshisuke Nakasato

Etsuo Ohshima

Kenji Ohmori

Michio Ichimura

Hitoshi Arai

Soichiro Sato

Hidee Ishii

Takashi Kawakita

Koji Yanagawa

Tohru Matsuzaki

Yukihito Tsukumo

Shuko Okazaki

Rie Koike

Takeshi Kuboyama

Hideyuki Onodera

Masayoshi Nakoji

Mayumi Saki

Setsuya Sasho

Naoko Hiura

Tsutomu Agatsuma

Takamichi Imaizumi

Jun Saito

Hidenori Takada

Kazuhiro Hibino

Fumitake Takizawa

Yuichi Matsumoto

Provided are a compound represented by general formula (I), or the pharmaceutically acceptable salt thereof, (wherein Rrepresents a hydrogen atom or the like, Rand Rmay be the same or different, and each represents a hydrogen atom, optionally substituted lower alkyl or cycloalkyl, or Rand Rare combined together with the adjacent nitrogen atom thereto to form nitrogen-containing heterocyclic group, and Z represents a bicyclic heterocyclic group in which optionally substituted two six-membered rings are fused to each other, or the like) and the like.

Pyrimidodiazepinone compound

The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xand Xare the same or different, and represent a bond or the like; R, R, R, R, Rand Rare the same or different, and represent a hydrogen atom or the like; Rand Rare the same or different, and represent a hydrogen atom or the like; Rrepresents a hydrogen atom or the like; Rand Rtogether represent a bond or the like; and Rrepresents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof. 

Sterol derivative

The present invention provides a preventive and/or therapeutic agent for neutrophilic inflammatory diseases which comprises, as an active ingredient, a bicyclic heterocyclic compound represented by formula (I): [wherein Rrepresents a hydrogen atom, substituted or unsubstituted alkyl, or the like, A-A-A-Arepresents N&#x2550;CR&#x2014;CR&#x2550;CR(wherein R, R, and Rare the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like), Q represents substituted or unsubstituted phenylene, and the like, and T represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aroyl, and the like].

Preventive and/or therapeutic agent for neutrophilic inflammatory diseases

The invention provides a pyrimidodiazepinone derivative represented by the general formula (I) [wherein n represents 1 or 2, Z represents a hydrogen atom or the like, Rand Rmay be the same or different, and each represents a hydrogen atom or the like, A represents a bond, (CH)(wherein m represents an integer of 1 to 4), optionally substituted phenylene, optionally substituted pyridinediyl, or C&#x2550;O, Rrepresents a hydrogen atom, optionally substituted lower alkyl, or the like, and Rrepresents a hydrogen atom or the like], or a pharmaceutically acceptable salt thereof or the like.

Pyrimidodiazepinone derivative

Derivatives of benzofuran or benzodioxazole compounds

Derivatives of benzofuran or benzodioxole

Growing community of inventors

Naka-gun, Japan

Kyoichiro Iida