Fujisawa Pharmaceutical Company, Ltd.

Kyoichi Shimomura

Masaaki Matsuo

Takashi Ogino

Norihiro Igari

Hachiro Seno

Fusako Nishigaki

Toshitaka Manda

A vascular permeability suppressant includes an oxaspirooctane derivative of the general formula (I):

Vascular-permeability suppressants

Compounds of the formula: ##STR1## wherein A is S, SO, or SO.sub.2, R.sup.1 is H or acyl, R.sup.2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R.sup.3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and thrombocytopenia.

Thiazole derivatives, processes for production thereof and

Compounds of the formula: ##STR1## wherein A is S, SO, or SO2, R1 is H or acyl, R2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and thrombocytopenia.

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Suita, Japan

Kyoichi Shimomura